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The effects of regular swimming exercise and melatonin on the neurons localized in the striatum of hemiparkinsonian rats

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dc.contributor.authorKİRAZLI, ÖZLEM
dc.contributor.authorBORACI, HATİCE
dc.contributor.authorYILDIZ, SERCAN DOĞUKAN
dc.contributor.authorYANANLI, HASAN RACİ
dc.contributor.authorŞEHİRLİ, ÜMİT SÜLEYMAN
dc.contributor.authorsGergin S., KİRAZLI Ö., BORACI H., YILDIZ S. D. , YANANLI H. R. , ŞEHİRLİ Ü. S.
dc.date.accessioned2022-10-25T12:04:24Z
dc.date.available2022-10-25T12:04:24Z
dc.date.issued2022-10-01
dc.description.abstractParkinson's disease is a progressive neurodegenerative movement disorder. We aimed to investigate the effects of regular swimming exercise and melatonin applied in the 6-Hydroxydopamine-induced Parkinson's disease rats by analysing dendritic spine of striatal neurons. Twenty-four male Wistar albino rats were used. 6-Hydroxydopamine unilaterally injected four (control, exercise, melatonin and exercise + melatonin) groups were included in the study. Tyrosine hydroxylase expression was detected by immunohistochemistry. Neurons and structures were identified from three-dimensional images by Neurolucida software. There was not any apparent difference for tyrosine hydroxylase positive neurons in the substantia nigra pars compacta and fibres in the striatum between the lesion sides of hemiparkinsonian groups. The treatment groups blocked the apomorphine-induced increase in rotations compared to the control group. In stepping test, the treatment groups prevented the loss of stepping in the contralateral side of hemiparkinsonian groups. The melatonin mostly had a positive effect on motor activity tests. In morphological analyses, the 6-Hydroxydopamine-induced lesion led to the reduction of the total dendritic length and number of branches. In the treatment groups, the reduction of the dendritic parameters was not observed. 6-Hydroxydopamine lesion led to a decrease in the total spine density, spine densities of thin and mushroom types. The exercise and melatonin treatments prevented the loss of spine density. The exercise treatment prevented the loss of spine density of mushroom type spines. The melatonin treatment blocked the loss of spine density of stubby type. In conclusion, these results provide evidence for effective additional protective therapeutic strategies for Parkinson\"s disease. In conclusion, results from the current study provide evidence for swimming exercise and melatonin as a promising candidate for effective additional protective strategies for PD.
dc.identifier.citationGergin S., KİRAZLI Ö., BORACI H., YILDIZ S. D. , YANANLI H. R. , ŞEHİRLİ Ü. S. , "The effects of regular swimming exercise and melatonin on the neurons localized in the striatum of hemiparkinsonian rats", ANATOMICAL SCIENCE INTERNATIONAL, 2022
dc.identifier.doi10.1007/s12565-022-00688-1
dc.identifier.issn1447-6959
dc.identifier.urihttps://hdl.handle.net/11424/282619
dc.language.isoeng
dc.relation.ispartofANATOMICAL SCIENCE INTERNATIONAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectAnatomi
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectHuman Anatomy
dc.subjectBiochemistry
dc.subjectNatural Sciences
dc.subjectANATOMİ VE MORFOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectANATOMY & MORPHOLOGY
dc.subjectBIOLOGY & BIOCHEMISTRY
dc.subjectLife Sciences (LIFE)
dc.subjectBiyokimya (tıbbi)
dc.subjectBiochemistry (medical)
dc.subjectAnatomy
dc.subjectDendritic spine
dc.subjectMelatonin
dc.subjectNeurolucida
dc.subjectPhysical exercise
dc.subjectStriatum
dc.subjectMEDIUM SPINY NEURONS
dc.subjectPARKINSONS-DISEASE
dc.subjectOXIDATIVE STRESS
dc.subjectMOUSE MODEL
dc.subjectL-DOPA
dc.subject6-HYDROXYDOPAMINE MODEL
dc.subjectPHYSICAL-ACTIVITY
dc.subjectDENDRITIC SPINES
dc.subjectROTENONE
dc.subjectPLASTICITY
dc.titleThe effects of regular swimming exercise and melatonin on the neurons localized in the striatum of hemiparkinsonian rats
dc.typearticle
dspace.entity.typePublication
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local.indexed.atPUBMED
local.indexed.atSCOPUS
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