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Clinical and immunological effects of azithromycin in Behcet's disease

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dc.contributor.authorMUMCU, GONCA
dc.contributor.authorsMumcu, G; Ergun, T; Elbir, Y; Eksioglu-Demiralp, E; Yavuz, S; Atalay, T; Direskeneli, H
dc.date.accessioned2022-03-12T17:18:44Z
dc.date.available2022-03-12T17:18:44Z
dc.date.issued2005
dc.description.abstractBACKGROUND: The aim of this study was to evaluate the effects of azithromycin on mucocutaneous manifestations, oral health and immune response in Behcet's disease (BD). METHODS: Eight BD patients with active mucocutaneous symptoms were treated with azithromycin for 4 weeks. Oral health, clinical manifestations and in vitro interleukin (IL)-12, interferon (IFN)-gamma, IL-10 and monocyte chemotactic protein (MCP)-1 responses were evaluated before and after treatment. RESULTS: The number of folliculitic lesions, healing time of oral ulcers and scores of plaque indexes (PLIs) were lower after azithromycin treatment (P < 0.05). Scores of PLIs correlated positively with the healing time of oral ulcers (P = 0.02). Although a trend towards increased stimulated IL-10 responses with azithromycin was observed, no statistically significant difference was found. Stimulated and unstimulated MCP-1, IFN-gamma and IL-12 responses were similar before and after treatment (P > 0.05). CONCLUSION: Azithromycin was observed to be effective in decreasing folliculitic lesions and fastening the healing time of oral ulcers in BD.
dc.identifier.doi10.1111/j.1600-0714.2004.00265.x
dc.identifier.eissn1600-0714
dc.identifier.issn0904-2512
dc.identifier.pubmed15610401
dc.identifier.urihttps://hdl.handle.net/11424/228003
dc.identifier.wosWOS:000225792200003
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF ORAL PATHOLOGY & MEDICINE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantimicrobial treatment
dc.subjectazithromycin
dc.subjectBehcet's disease
dc.subjectcytokines and chemokines
dc.subjectPERIODONTAL TISSUE DISPOSITION
dc.subjectSYMPTOMS
dc.subjectPNEUMONIAE
dc.subjectCOLCHICINE
dc.subjectMACROLIDES
dc.subjectINFECTION
dc.subjectINDUCTION
dc.subjectANTIGENS
dc.titleClinical and immunological effects of azithromycin in Behcet's disease
dc.typearticle
dspace.entity.typePublication
local.avesis.id461b7285-2f61-4ad2-bf35-d9012cd6342c
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages4
oaire.citation.endPage16
oaire.citation.issue1
oaire.citation.startPage13
oaire.citation.titleJOURNAL OF ORAL PATHOLOGY & MEDICINE
oaire.citation.volume34
relation.isAuthorOfPublication15fb5c8c-4e72-485b-bf3d-c6e191e3f5aa
relation.isAuthorOfPublication.latestForDiscovery15fb5c8c-4e72-485b-bf3d-c6e191e3f5aa

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