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Nesfatin-1 alleviates extrahepatic cholestatic damage of liver in rats

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dc.contributor.authorERZİK, CAN
dc.contributor.authorsSolmaz, Ali; Gulcicek, Osman Bilgin; Ercetin, Candas; Yigitbas, Hakan; Yavuz, Erkan; Arici, Sinan; Erzik, Can; Zengi, Oguzhan; Demirturk, Pelin; Celik, Atilla; Celebi, Fatih
dc.date.accessioned2022-03-14T08:14:19Z
dc.date.available2022-03-14T08:14:19Z
dc.date.issued2016-11-10
dc.description.abstractObstructive jaundice (OJ) can be defined as cessation of bile flow into the small intestine due to benign or malignant changes. Nesfatin-1, recently discovered anorexigenic peptide derived from nucleobindin-2 in hypothalamic nuclei, was shown to have anti-inflammatory and antiapoptotic effects. This study is aimed to investigate the therapeutic effects of nesfatin-1 on OJ in rats. Twenty-four adult male Wistar-Hannover rats were randomly assigned to three groups: sham (n = 8), control (n = 8), and nesfatin (n = 8). After bile duct ligation, the study groups were treated with saline or nesfatin-1, for 10 days. Afterward, blood and liver tissue samples were obtained for biochemical analyses, measurement of cytokines, determination of the oxidative DNA damage, DNA fragmentation, and histopathologic analyses. Alanine aminotransferase and gamma-glutamyl transferase levels were decreased after the nesfatin treatment; however, these drops were statistically non-significant compared to control group (p = 0.345, p = 0.114). Malondialdehyde levels decreased significantly in nesfatin group compared to control group (p = 0.032). Decreases in interleukin-6 and tumor necrosis factor-a levels from the liver tissue samples were not statistically significant in nesfatin group compared to control group. The level of oxidative DNA damage was lower in nesfatin group, however this result was not statistically significant (p = 0.75). DNA fragmentation results of all groups were similar. Histopathological examination revealed that there was less neutrophil infiltration, edema, bile duct proliferation, hepatocyte necrosis, basement membrane damage, and parenchymal necrosis in nesfatin compared to control group. The nesfatin-1 treatment could alleviate cholestatic liver damage caused by OJ due to its anti-inflammatory and antioxidant effects.
dc.identifier.doi10.17305/bjbms.2016.1465
dc.identifier.eissn1840-4812
dc.identifier.issn1512-8601
dc.identifier.pubmed27524109
dc.identifier.urihttps://hdl.handle.net/11424/241229
dc.identifier.wosWOS:000388033500002
dc.language.isoeng
dc.publisherASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVO
dc.relation.ispartofBOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectObstructive jaundice
dc.subjectoxidative stress
dc.subjecthepatic damage
dc.subjectcholestasis
dc.subjectDNA fragmentation
dc.subjectBILE-DUCT OBSTRUCTION
dc.subjectOXIDATIVE STRESS
dc.subjectDEOXYRIBONUCLEIC-ACID
dc.subjectLIPID-PEROXIDATION
dc.subjectMELATONIN
dc.subjectJAUNDICE
dc.subjectINJURY
dc.subjectANTIOXIDANTS
dc.subjectHEPATOCYTES
dc.subjectMECHANISMS
dc.titleNesfatin-1 alleviates extrahepatic cholestatic damage of liver in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id5c12fb60-21d8-4005-9e7b-262c70d3f5a5
local.import.packageSS16
local.indexed.atWOS
local.journal.numberofpages7
local.journal.quartileQ4
oaire.citation.endPage253
oaire.citation.issue4
oaire.citation.startPage247
oaire.citation.titleBOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
oaire.citation.volume16
relation.isAuthorOfPublication5081a883-9590-4d5d-8e2a-f83c8916241d
relation.isAuthorOfPublication.latestForDiscovery5081a883-9590-4d5d-8e2a-f83c8916241d

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