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Magnetic nanoparticle containing thiol-ene crosslinked hydrogels for controlled and targeted release of hydrophobic drugs

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dc.contributor.authorOKTAY, BURCU
dc.contributor.authorsOktay, Burcu; Demir, Serap; Kayaman-Apohan, Nilhan
dc.date.accessioned2022-03-12T22:24:36Z
dc.date.available2022-03-12T22:24:36Z
dc.date.issued2018
dc.description.abstractThis study reports a straightforward but very effective method to produce nanocomposite hydrogels for targeted drug delivery system. An organic network containing both hydrophilic and hydrophobic components was obtained using thiol-ene cross-linking. Magnetite nanoparticles (MNPs) were synthesized by chemical co-precipitation. The surface of the MNPs was modified with allyl groups to avoid agglomeration. Composite hydrogels were prepared by addition of surface modified MNPs to hydrogel formulation at different ratios. The prepared composite hydrogels were investigated for their ability to loading and release hydrophobic drugs tamoxifen and clarithromycin. The morphological and structural characterizations of MNPs were performed by Fourier transform infrared spectroscopy (FT-IR) and Environmental scanning electron microscopy (SEM) and Environmental scanning transmission electron microscopy (STEM). Moreover the superparamagnetic behavior of the hydrogels was studied by a vibrating sample magnetometer (VSM). The saturation magnetization values increased with the magnetite content. Swelling, gel content and degradation of the hydrogels were examined. According to the loading of drugs, the maximum loading efficiency was 91% for tamoxifen and 70% for clarithromycin due to the stronger hydrophobic interactions. In vitro release studies showed that controlled release of the drugs occurred over a prolonged period of time. Therefore, drug loaded hydrogels can be considered as potential long-term sustained drug release systems. POLYM. COMPOS., 39:E200-E209, 2018. (c) 2016 Society of Plastics Engineers
dc.identifier.doi10.1002/pc.24144
dc.identifier.eissn1548-0569
dc.identifier.issn0272-8397
dc.identifier.urihttps://hdl.handle.net/11424/234798
dc.identifier.wosWOS:000430691500017
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofPOLYMER COMPOSITES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIRON-OXIDE NANOPARTICLES
dc.subjectBIOMEDICAL APPLICATIONS
dc.subjectDELIVERY SYSTEMS
dc.subjectNANOCOMPOSITE HYDROGELS
dc.subjectHYDROLYTIC DEGRADATION
dc.subjectCOPOLYMERS
dc.subjectCHITOSAN
dc.subjectCANCER
dc.subjectFE3O4
dc.subjectBRAIN
dc.titleMagnetic nanoparticle containing thiol-ene crosslinked hydrogels for controlled and targeted release of hydrophobic drugs
dc.typearticle
dspace.entity.typePublication
local.avesis.idd87cc687-1a56-466c-a543-e12bcf11abc6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages10
local.journal.quartileQ2
oaire.citation.endPageE209
oaire.citation.startPageE200
oaire.citation.titlePOLYMER COMPOSITES
oaire.citation.volume39
relation.isAuthorOfPublication73bf1f8b-c472-46a3-8ef3-f25a516fef62
relation.isAuthorOfPublication.latestForDiscovery73bf1f8b-c472-46a3-8ef3-f25a516fef62

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