Publication: Outcome of hypogammaglobulinemia in children: Immunoglobulin levels as predictors
dc.contributor.author | ÖZEN, AHMET OĞUZHAN | |
dc.contributor.authors | Ozen, Ahmet; Baris, Safa; Karakoc-Aydiner, Elif; Ozdemir, Cevdet; Bahceciler, Nerin Nadir; Barlan, Isil Berat | |
dc.date.accessioned | 2022-03-12T17:48:25Z | |
dc.date.available | 2022-03-12T17:48:25Z | |
dc.date.issued | 2010 | |
dc.description.abstract | We evaluated 131 children (M=88, F=43) with hypogammaglobulinemia Data was analyzed mainly for delineating predictor factors for outcome The distance from the lower limit of normal (-2SD) for any single measurement of immunoglobulins (Ig) was calculated and transformed into Ig scores Mean age and duration of follow up were 5 06 +/- 4 05 and 3 7 +/- 3 03 years, respectively The diagnoses were 22 CVID, 16 IgA deficiency, 33 transient hypogammaglobulinemia of childhood (THC), 3 selective IgM deficiency and 57 unclassified hypogammaglobulinemia (UCH) Low IgA scores (<-0 124) at presentation were indicative of subsequent development of IgA deficiency or CVID, whereas low IgM score (<-0 038) pointed towards more severe and persistent phenotypes Combination of low IgM score between 2 and 5 years, impaired antibody response and low B cell counts enabled us to predict persistence of hypogammaglobulinemia beyond 5 years (specificity = 90 5% and PPV = 94 9%) and chronic lung disease (sensitivity =90 4% and specificity = 68 3%) The set of criteria including low IgM scores, impaired antibody response and low B cell counts provided a high predictive value in detecting those with persistent hypogammaglobulinemia (C) 2010 Elsevier Inc All rights reserved | |
dc.identifier.doi | 10.1016/j.clim.2010.08.010 | |
dc.identifier.issn | 1521-6616 | |
dc.identifier.pubmed | 20851686 | |
dc.identifier.uri | https://hdl.handle.net/11424/229953 | |
dc.identifier.wos | WOS:000284300600009 | |
dc.language.iso | eng | |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | |
dc.relation.ispartof | CLINICAL IMMUNOLOGY | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | THI | |
dc.subject | CVID | |
dc.subject | Unclassified Hypogammaglobulinemia | |
dc.subject | Predictors | |
dc.subject | Outcome | |
dc.subject | Allergy | |
dc.subject | B cell | |
dc.subject | Antibody response | |
dc.subject | Immunoglobulin level | |
dc.subject | IgM | |
dc.subject | SELECTIVE IGA DEFICIENCY | |
dc.subject | TRANSIENT HYPOGAMMAGLOBULINEMIA | |
dc.subject | PRIMARY IMMUNODEFICIENCIES | |
dc.subject | EARLY-CHILDHOOD | |
dc.subject | INFANCY | |
dc.subject | TURKEY | |
dc.title | Outcome of hypogammaglobulinemia in children: Immunoglobulin levels as predictors | |
dc.type | article | |
dspace.entity.type | Publication | |
local.avesis.id | aaf5e049-046a-4726-856c-72b800400341 | |
local.import.package | SS17 | |
local.indexed.at | WOS | |
local.indexed.at | SCOPUS | |
local.journal.numberofpages | 10 | |
oaire.citation.endPage | 383 | |
oaire.citation.issue | 3 | |
oaire.citation.startPage | 374 | |
oaire.citation.title | CLINICAL IMMUNOLOGY | |
oaire.citation.volume | 137 | |
relation.isAuthorOfPublication | 3e9c297b-e636-4836-8f61-dc9c8b7c29cf | |
relation.isAuthorOfPublication.latestForDiscovery | 3e9c297b-e636-4836-8f61-dc9c8b7c29cf |