Publication:
Outcome of hypogammaglobulinemia in children: Immunoglobulin levels as predictors

dc.contributor.authorÖZEN, AHMET OĞUZHAN
dc.contributor.authorsOzen, Ahmet; Baris, Safa; Karakoc-Aydiner, Elif; Ozdemir, Cevdet; Bahceciler, Nerin Nadir; Barlan, Isil Berat
dc.date.accessioned2022-03-12T17:48:25Z
dc.date.available2022-03-12T17:48:25Z
dc.date.issued2010
dc.description.abstractWe evaluated 131 children (M=88, F=43) with hypogammaglobulinemia Data was analyzed mainly for delineating predictor factors for outcome The distance from the lower limit of normal (-2SD) for any single measurement of immunoglobulins (Ig) was calculated and transformed into Ig scores Mean age and duration of follow up were 5 06 +/- 4 05 and 3 7 +/- 3 03 years, respectively The diagnoses were 22 CVID, 16 IgA deficiency, 33 transient hypogammaglobulinemia of childhood (THC), 3 selective IgM deficiency and 57 unclassified hypogammaglobulinemia (UCH) Low IgA scores (<-0 124) at presentation were indicative of subsequent development of IgA deficiency or CVID, whereas low IgM score (<-0 038) pointed towards more severe and persistent phenotypes Combination of low IgM score between 2 and 5 years, impaired antibody response and low B cell counts enabled us to predict persistence of hypogammaglobulinemia beyond 5 years (specificity = 90 5% and PPV = 94 9%) and chronic lung disease (sensitivity =90 4% and specificity = 68 3%) The set of criteria including low IgM scores, impaired antibody response and low B cell counts provided a high predictive value in detecting those with persistent hypogammaglobulinemia (C) 2010 Elsevier Inc All rights reserved
dc.identifier.doi10.1016/j.clim.2010.08.010
dc.identifier.issn1521-6616
dc.identifier.pubmed20851686
dc.identifier.urihttps://hdl.handle.net/11424/229953
dc.identifier.wosWOS:000284300600009
dc.language.isoeng
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartofCLINICAL IMMUNOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTHI
dc.subjectCVID
dc.subjectUnclassified Hypogammaglobulinemia
dc.subjectPredictors
dc.subjectOutcome
dc.subjectAllergy
dc.subjectB cell
dc.subjectAntibody response
dc.subjectImmunoglobulin level
dc.subjectIgM
dc.subjectSELECTIVE IGA DEFICIENCY
dc.subjectTRANSIENT HYPOGAMMAGLOBULINEMIA
dc.subjectPRIMARY IMMUNODEFICIENCIES
dc.subjectEARLY-CHILDHOOD
dc.subjectINFANCY
dc.subjectTURKEY
dc.titleOutcome of hypogammaglobulinemia in children: Immunoglobulin levels as predictors
dc.typearticle
dspace.entity.typePublication
local.avesis.idaaf5e049-046a-4726-856c-72b800400341
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages10
oaire.citation.endPage383
oaire.citation.issue3
oaire.citation.startPage374
oaire.citation.titleCLINICAL IMMUNOLOGY
oaire.citation.volume137
relation.isAuthorOfPublication3e9c297b-e636-4836-8f61-dc9c8b7c29cf
relation.isAuthorOfPublication.latestForDiscovery3e9c297b-e636-4836-8f61-dc9c8b7c29cf

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