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Inhibitory effects of gastrin releasing peptide on gastric emptying in rats

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsYegen, BC; Gurbuz, V; Coskun, T; Bozkurt, A; Kurtel, H; Alican, I; Dockray, GJ
dc.date.accessioned2022-03-12T16:56:31Z
dc.date.available2022-03-12T16:56:31Z
dc.date.issued1996
dc.description.abstractGastrin-releasing peptide (GRP) has a wide range of biological actions, including stimulation of the frequency of antral contractions and delaying gastric emptying. The present study was designed to evaluate the role of GRP in the control of gastric emptying of liquid test meals in the rat. The emptying of methyl cellulose given by gavage to fasted rats, or of saline given via the fistula to conscious gastric fistula rats was not influenced by the GRP antagonists, NC-8-89 (Leu(13)-psi-(CH2NH)-Leu(14)-bombesin) and 2258U89 ((de-NH2)Phe(19),D-Ala(24),D-Pro(26)psi (CH2NH)Phe(27)(-GRP (19-27)), at 2 mg/kg, s.c. However, both antagonists (0.02, 0.2 and 2 mg/kg) reversed the inhibitory effect of HCl on gastric emptying in gastric fistula rats (P < 0.05-0.001). When peptone was administered after a preload, but not otherwise, the inhibition of emptying was also partly reversed by both antagonists at all doses used (P < 0.05-0.001). Interestingly, the delay in the emptying of hyperosmolal saline compared to saline, was enhanced at a dose of 0.2 mg/kg of both antagonists (P < 0.05 and P < 0.01). Food intake did not change significantly with the two lower doses of antagonists, but was decreased by the highest dose of NC 8-89. We conclude that GRP specifically inhibits gastric emptying of acid and peptone solutions in the conscious rat.
dc.identifier.doi10.1016/0167-0115(95)00151-4
dc.identifier.issn0167-0115
dc.identifier.pubmed8701033
dc.identifier.urihttps://hdl.handle.net/11424/226780
dc.identifier.wosWOS:A1996UK53400002
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofREGULATORY PEPTIDES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectgastrin-releasing peptide
dc.subjectgastric emptying
dc.subjectpeptone
dc.subjectHCl
dc.subjectBOMBESIN RECEPTOR ANTAGONISTS
dc.subjectPRIMARY CULTURE
dc.subjectCONSCIOUS CATS
dc.subjectCHOLECYSTOKININ
dc.subjectCELLS
dc.subjectRELAXATION
dc.subjectSTIMULATION
dc.subjectSECRETION
dc.subjectMOTILITY
dc.subjectMEDIATOR
dc.titleInhibitory effects of gastrin releasing peptide on gastric emptying in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id665bdda7-46fa-4b0f-82e4-331f1a9f7568
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage180
oaire.citation.issue3
oaire.citation.startPage175
oaire.citation.titleREGULATORY PEPTIDES
oaire.citation.volume61
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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