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The distribution of the bft alleles among enterotoxigenic Bacteroides fragilis strains from stool specimens and extraintestinal sites

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dc.contributor.authorKARAHASAN, AYŞEGÜL
dc.contributor.authorsUlger, N; Rajendram, D; Yagci, A; Gharbia, S; Shah, HN; Gulluoglu, BM; Akin, LM; Demirkalem, P; Celenk, T; Soyletir, G
dc.date.accessioned2022-03-12T17:21:59Z
dc.date.available2022-03-12T17:21:59Z
dc.date.issued2006
dc.description.abstractEnterotoxigenic Bacteroides fragilis (ETBF) has been implicated in diarrhoeal illness in animals and humans. Recent data Suggest that ETBF is associated with flares of inflammatory bowel disease. Toxigenicity is attributed to expression of a toxin referred to as fragilysin, which stimulates fluid accumulation in ligated intestinal segments and alter the morphology or human intestinal cells. Three different isoforms or variants of the enterotoxin gene, designated bft-1, bft-2, and bft-3, have been identified. In this study we investigated the distribution of bft alleles among ETBF strains in stool specimens from patients with colon cancer (n:31), the control patients (n: 8) and extraintestinal sources (n: 15). We used restriction fragment length polymorphism analysis of the PCR-amplified enterotoxin gene and sequencing the PCR-product to detect the isoforms of bft gene. Among the stool strains, bft-1 was found to be more common than bft-2; as it was detected 27 of 31 strains from colon cancer patients and 7 of 8 control strains. The bft-1 isoform was also found in almost all isolates from extraintestinal sites. No bft-3 subtype was detected among all tested strains. (C) 2005 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.anaerobe.2005.11.001
dc.identifier.issn1075-9964
dc.identifier.pubmed16701617
dc.identifier.urihttps://hdl.handle.net/11424/228382
dc.identifier.wosWOS:000236244200004
dc.language.isoeng
dc.publisherACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
dc.relation.ispartofANAEROBE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectenterotoxigenc
dc.subjectBacteroides fragilis
dc.subjectcolon cancer
dc.subjectfragilysin
dc.subjectbft alleles
dc.subjectINFLAMMATORY-BOWEL-DISEASE
dc.subjectMETALLOPROTEASE TOXIN GENE
dc.subjectCHILDREN
dc.subjectDIARRHEA
dc.subjectJAPAN
dc.titleThe distribution of the bft alleles among enterotoxigenic Bacteroides fragilis strains from stool specimens and extraintestinal sites
dc.typearticle
dspace.entity.typePublication
local.avesis.id5e37bdd1-47e9-4790-9d4a-70c901a2c322
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages4
oaire.citation.endPage74
oaire.citation.issue2
oaire.citation.startPage71
oaire.citation.titleANAEROBE
oaire.citation.volume12
relation.isAuthorOfPublicationd8b6c313-4dc1-4253-adf4-6e2e6d68af90
relation.isAuthorOfPublication.latestForDiscoveryd8b6c313-4dc1-4253-adf4-6e2e6d68af90

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