Publication:
Late Diagnosis of Infants with PCD and Neonatal Respiratory Distress

Simple item page
dc.contributor.authorKARADAĞ, BÜLENT TANER
dc.contributor.authorsGoutaki, Myrofora; Halbeisen, Florian S.; Barbato, Angelo; Crowley, Suzanne; Harris, Amanda; Hirst, Robert A.; Karadag, Bulent; Martinu, Vendula; Morgan, Lucy; O'Callaghan, Christopher; Ozcelik, Ugur; Scigliano, Sergio; Ucros, Santiago; Yiallouros, Panayiotis; Schulzke, Sven M.; Kuehni, Claudia E.
dc.date.accessioned2022-03-14T09:29:28Z
dc.date.available2022-03-14T09:29:28Z
dc.date.issued2020-09-04
dc.description.abstractNeonatal respiratory distress (NRD) is common among infants with primary ciliary dyskinesia (PCD), but we do not know whether affected neonates receive a timely diagnosis. We used data from the international PCD cohort and assessed the proportion of patients with PCD who had a history of NRD and their age at diagnosis, stratifying by presence of laterality defects. First we analyzed data from all participants diagnosed after 2000, followed by individuals from a subgroup diagnosed using stricter criteria. Among the 1375 patients in the study, 45% had a history of NRD and 42% had laterality defects. Out of the 476 children with definite PCD diagnosis, 55% had a history of NRD and 50% had laterality defects. Overall, 30% of children with PCD were diagnosed during the first 12 months of life. This varied from 13% in those with situs solitus and no NRD, to 21% in those with situs solitus and NRD, 33% in those with situs anomalies but no NRD, and 52% in those with both situs anomalies and NRD. Our results suggest that we need to improve our knowledge of the neonatal presentation of infants with PCD and apply it so that these patients will receive appropriate care sooner.
dc.identifier.doi10.3390/jcm9092871
dc.identifier.eissn2077-0383
dc.identifier.pubmed32899853
dc.identifier.urihttps://hdl.handle.net/11424/243188
dc.identifier.wosWOS:000580699600001
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofJOURNAL OF CLINICAL MEDICINE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectprimary ciliary dyskinesia
dc.subjectneonatal respiratory distress
dc.subjectlaterality defect
dc.subjectorphan diseases
dc.subjectPRIMARY CILIARY DYSKINESIA
dc.subjectDEFECTS
dc.titleLate Diagnosis of Infants with PCD and Neonatal Respiratory Distress
dc.typearticle
dspace.entity.typePublication
local.avesis.id72b00169-84e8-4e99-b54a-fd1f7d077f56
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber2871
local.journal.numberofpages9
local.journal.quartileQ1
oaire.citation.issue9
oaire.citation.titleJOURNAL OF CLINICAL MEDICINE
oaire.citation.volume9
relation.isAuthorOfPublication218b489d-97ab-49dd-9db6-0c2a732f1999
relation.isAuthorOfPublication.latestForDiscovery218b489d-97ab-49dd-9db6-0c2a732f1999

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Goutaki et al. - 2020 - Late Diagnosis of Infants with PCD and Neonatal Re.pdf
Size:
1.05 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs