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Duration of ciprofloxacin use is important in the development of abdominal aortic aneurysm in a rat model

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dc.contributor.authorÖZYILMAZ YAY, NAGEHAN
dc.contributor.authorERGELEN, RABİA
dc.contributor.authorAKAKIN, DİLEK
dc.contributor.authorGÜLHAN, REZZAN
dc.contributor.authorsÇulpan Y., Keçeci İ., Sandıkçı İ., Gökçe Ş., Göker H., ÖZYILMAZ YAY N., ERGELEN R., AKAKIN D., GÜLHAN R.
dc.date.accessioned2022-12-27T08:39:26Z
dc.date.available2022-12-27T08:39:26Z
dc.date.issued2022-11-01
dc.description.abstractBACKGROUND: Recent findings suggest that fluoroquinolones, most prescribed antibiotic to treat various infections, have increased abdominal aortic aneurysm formation. We aimed to investigate the relation of the development of abdominal aortic aneurysm and the duration of ciprofloxacin use. METHODS: Male Sprague-Dawley rats were divided into 2 groups to administer saline to the control groups and CaCl2 to the aneurysm groups. These groups were then divided into 3 subgroups: intraperitoneal saline, ciprofloxacin for 2 weeks, and ciprofloxacin for 4 weeks. At the end of 4 weeks, the diameter of abdominal aorta was determined by ultrasonography and animals were sacrificed to obtain abdominal aorta specimens. Elastic fiber fracture, tunica media layer thickness, and aortic tissue damage were evaluated histologically. RESULTS: Aortic diameter of control-saline (2.15 mm ± 0.06), control-2 weeks (2.25 mm ± 0.06), and control-4 weeks (3.31 mm ± 0.09) ciprofloxacin groups was significantly different (P .05). CONCLUSION: The study showed that ciprofloxacin caused injury in the aortic wall but not a significant change in the thickness of the aortic tunica media layer. The duration of ciprofloxacin use was important in the development of aneurysm and aneurysm severity.
dc.identifier.citationÇulpan Y., Keçeci İ., Sandıkçı İ., Gökçe Ş., Göker H., ÖZYILMAZ YAY N., ERGELEN R., AKAKIN D., GÜLHAN R., "Duration of Ciprofloxacin Use Is Important in the Development of Abdominal Aortic Aneurysm in a Rat Model", Anatolian journal of cardiology, cilt.26, sa.11, ss.810-817, 2022
dc.identifier.doi10.5152/anatoljcardiol.2022.1939
dc.identifier.endpage817
dc.identifier.issn2149-2271
dc.identifier.issue11
dc.identifier.startpage810
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85141003652&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/284225
dc.identifier.volume26
dc.language.isoeng
dc.relation.ispartofAnatolian journal of cardiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectKardiyoloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectCardiovascular
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKALP VE KALP DAMAR SİSTEMLERİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectCARDIAC & CARDIOVASCULAR SYSTEMS
dc.subjectKardiyoloji ve Kardiyovasküler Tıp
dc.subjectCardiology and Cardiovascular Medicine
dc.titleDuration of ciprofloxacin use is important in the development of abdominal aortic aneurysm in a rat model
dc.typearticle
dspace.entity.typePublication
local.avesis.idc8b158bb-2dc0-49ae-b225-fb2d02fee517
local.indexed.atPUBMED
local.indexed.atSCOPUS
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