Publication:
Association between the growth arrest-specific 6 (Gas6) gene polymorphism c.834+7G > A and preeclampsia

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dc.contributor.authorBİNGÖL ÖZAKPINAR, ÖZLEM
dc.contributor.authorsOzakpinar, Ozlem Bingol; Sahin, Sadik; Verimli, Nihan; Simsek, Gulhayat Golbasi; Maurer, Anne-Marie; Eroglu, Mustafa; Tetik, Sermin; Uras, Fikriye
dc.date.accessioned2022-03-12T20:29:10Z
dc.date.available2022-03-12T20:29:10Z
dc.date.issued2016
dc.description.abstractObjective: Preeclampsia (PE) is a hypertensive disease of pregnancy complicating 2-8% of all pregnancies. The exact pathophysiology still remains unknown. Growth arrest-specific 6 (Gas6) is a member of the vitamin K-dependent protein family and it has been suggested as a novel atherothrombotic risk factor with anti-angiogenic and pro-atherogenic properties. The goal of the our study was to investigate the relationships between the c.834+7G>A polymorphism of GAS6, plasma Gas6 levels and PE.Methods: A total of 150 women, including 82 preeclamptic pregnant women and 68 normotensive pregnant (NP) women, were recruited in the current study. Blood samples were taken from all participitants. Plasma Gas6 levels measured by an enzyme-linked immunosorbent assay. GAS6 polymorphism was determined using a PCR-RFLP method.Results: The plasma Gas6 levels of preeclamptic patients were significantly lower than those of NP women (8.653.70ng/ml and 10.89 +/- 4.23ng/ml respectively, p<0.001). The GG genotype was the most prevalent, and the risk of PE was 3.5-fold higher in pregnant women with GG genotype compared to woman with AA genotype (p<0.01). The A allele was less frequent in preeclamptic patients than in control subjects (OR=2.118, 95% CI=1.330-3.371, p<0.001).Conclusions: Our results suggest that GAS6 c.834+7G>A polymorphism may have a pivotal role in the pathogenesis of PE suggesting that the A allele has a protective role for PE.
dc.identifier.doi10.3109/14767058.2015.1038516
dc.identifier.eissn1476-4954
dc.identifier.issn1476-7058
dc.identifier.pubmed25915719
dc.identifier.urihttps://hdl.handle.net/11424/234035
dc.identifier.wosWOS:000368710600025
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGAS6 polymorphism
dc.subjectinflammation
dc.subjectpreeclampsia
dc.subjectKINASE RECEPTOR AXL
dc.subjectENDOTHELIAL-CELLS
dc.subjectPLASMA-CONCENTRATIONS
dc.subjectSMOOTH-MUSCLE
dc.subjectPROTEIN
dc.subjectINFLAMMATION
dc.subjectEXPRESSION
dc.titleAssociation between the growth arrest-specific 6 (Gas6) gene polymorphism c.834+7G > A and preeclampsia
dc.typearticle
dspace.entity.typePublication
local.avesis.id4bb93f33-8792-416c-bae9-4b132433a454
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
local.journal.quartileQ3
oaire.citation.endPage1153
oaire.citation.issue7
oaire.citation.startPage1149
oaire.citation.titleJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
oaire.citation.volume29
relation.isAuthorOfPublication44b61e5d-4045-4d63-926e-2f01c3ee5642
relation.isAuthorOfPublication.latestForDiscovery44b61e5d-4045-4d63-926e-2f01c3ee5642

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