Publication:
Alpha-Lipoic Acid Improves Acetic Acid-Induced Gastric Ulcer Healing in Rats

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsKarakoyun, Berna; Yuksel, Meral; Ercan, Feriha; Erzik, Can; Yegen, Berrak C.
dc.date.accessioned2022-03-12T16:00:42Z
dc.date.available2022-03-12T16:00:42Z
dc.date.issued2009
dc.description.abstractTo evaluate the role of ALA treatment on the healing of acetic acid-induced gastric ulcer, rats were given ALA (35 mg/kg/day) or saline for 3 days before the induction of ulcer and the treatment was continued twice daily for 2 days (early) or 10 days (late) until they were decapitated. Gastric ulcer index, microscopic score, elevated DNA fragmentation and chemiluminescence levels of the saline-treated ulcer groups were all reduced by ALA treatment. Likewise, ALA treatment inhibited chemiluminescence levels in both early and late ulcer groups. Marked reduction in glutathione levels of the saline-treated early ulcer group was reversed by ALA treatment, while ALA treatment was effective in depressing gastric myeloperoxidase activity in the late ulcer group. In conclusion, ALA treatment shows protective role in the healing of acetic acid-induced gastric injury in rats via the suppression of neutrophil accumulation, preservation of endogenous glutathione, inhibition of reactive oxidant generation and apoptosis.
dc.identifier.doi10.1007/s10753-008-9100-4
dc.identifier.eissn1573-2576
dc.identifier.issn0360-3997
dc.identifier.pubmed19051000
dc.identifier.urihttps://hdl.handle.net/11424/224730
dc.identifier.wosWOS:000262504900005
dc.language.isoeng
dc.publisherSPRINGER/PLENUM PUBLISHERS
dc.relation.ispartofINFLAMMATION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectalpha-lipoic acid
dc.subjectulcer healing
dc.subjectacetic acid
dc.subjectoxidant damage
dc.subjectapoptosis
dc.subjectNF-KAPPA-B
dc.subjectOXIDATIVE STRESS
dc.subjectLIPID-PEROXIDATION
dc.subjectGENE-EXPRESSION
dc.subjectL-CARNITINE
dc.subjectANTIOXIDANT
dc.subjectAPOPTOSIS
dc.subjectCELLS
dc.subjectDAMAGE
dc.subjectINFLAMMATION
dc.titleAlpha-Lipoic Acid Improves Acetic Acid-Induced Gastric Ulcer Healing in Rats
dc.typeconferenceObject
dspace.entity.typePublication
local.avesis.id7a4b0bf0-6e42-4e84-ba39-0275d1f9d291
local.conference.dateMAY 17-22, 2008
local.conference.locationSan Diego, CA
local.conference.sponsorAmer Gastroenterol Assoc
local.conference.titleDigestive Disease Week Meeting/109th Annual Meeting of the American-Gastroenterological-Association
local.import.packageSS15
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
oaire.citation.endPage46
oaire.citation.issue1
oaire.citation.startPage37
oaire.citation.titleINFLAMMATION
oaire.citation.volume32
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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