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Toward Precision Oncology in Glioblastoma with a Personalized Cancer Genome Reporting Tool and Genetic Changes Identified by Whole Exome Sequencing

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dc.contributor.authorERDOĞAN, ONUR
dc.contributor.authorERZİK, CAN
dc.contributor.authorARĞA, KAZIM YALÇIN
dc.contributor.authorBAYRAKLI, FATİH
dc.contributor.authorsERDOĞAN O., Özkaya Ş. Ç., ERZİK C., Bilguvar K., ARGA K. Y., BAYRAKLI F.
dc.date.accessioned2023-09-26T05:47:04Z
dc.date.available2023-09-26T05:47:04Z
dc.date.issued2023-09-01
dc.description.abstractPrecision/personalized medicine in oncology has two key pillars: molecular profiling of the tumors and personalized reporting of the results in ways that are clinically contextualized and triangulated. Moreover, neurosurgery as a field stands to benefit from precision/personalized medicine and new tools for reporting of the molecular findings. In this context, glioblastoma (GBM) is a highly aggressive brain tumor with limited treatment options and poor prognosis. Precision/personalized medicine has emerged as a promising approach for personalized therapy in GBM. In this study, we performed whole exome sequencing of tumor tissue samples from six newly diagnosed GBM patients and matched nontumor control samples. We report here the genetic alterations identified in the tumors, including single nucleotide variations, insertions or deletions (indels), and copy number variations, and attendant mutational signatures. Additionally, using a personalized cancer genome-reporting tool, we linked genomic information to potential therapeutic targets and treatment options for each patient. Our findings revealed heterogeneity in genetic alterations and identified targetable pathways, such as the PI3K/AKT/mTOR pathway. This study demonstrates the prospects of precision/personalized medicine in GBM specifically, and neurosurgical oncology more generally, including the potential for genomic profiling coupled with personalized cancer genome reporting. Further research and larger studies are warranted to validate these findings and advance the treatment options and outcomes for patients with GBM.
dc.identifier.citationERDOĞAN O., Özkaya Ş. Ç., ERZİK C., Bilguvar K., ARGA K. Y., BAYRAKLI F., "Toward Precision Oncology in Glioblastoma with a Personalized Cancer Genome Reporting Tool and Genetic Changes Identified by Whole Exome Sequencing", Omics : a journal of integrative biology, cilt.27, sa.9, ss.426-433, 2023
dc.identifier.doi10.1089/omi.2023.0117
dc.identifier.endpage433
dc.identifier.issn1557-8100
dc.identifier.issue9
dc.identifier.startpage426
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85171309786&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/293675
dc.identifier.volume27
dc.language.isoeng
dc.relation.ispartofOmics : a journal of integrative biology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectMedical Genetics
dc.subjectLife Sciences
dc.subjectBiotechnology
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMikrobiyoloji
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectGENETİK VE KALITIM
dc.subjectLife Sciences (LIFE)
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectMICROBIOLOGY
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectBIOTECHNOLOGY & APPLIED MICROBIOLOGY
dc.subjectGENETICS & HEREDITY
dc.subjectBiyokimya
dc.subjectMoleküler Tıp
dc.subjectMoleküler Biyoloji
dc.subjectGenetik
dc.subjectBiochemistry
dc.subjectMolecular Medicine
dc.subjectMolecular Biology
dc.subjectGenetics
dc.subjectgenomics
dc.subjectglioblastoma
dc.subjectpersonalized medicine
dc.subjectprecision oncology
dc.subjectwhole exome sequencing
dc.titleToward Precision Oncology in Glioblastoma with a Personalized Cancer Genome Reporting Tool and Genetic Changes Identified by Whole Exome Sequencing
dc.typearticle
dspace.entity.typePublication
local.avesis.idd7f752a9-3f95-4273-a809-6e5e39298e43
local.indexed.atPUBMED
local.indexed.atSCOPUS
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