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The pathways connecting the hippocampal formation, the thalamic reuniens nucleus and the thalamic reticular nucleus in the rat

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsCavdar, Safiye; Onat, Filiz Y.; Cakmak, Yusuf Oezguer; Yananli, Hasan R.; Gulcebi, Medine; Aker, Rezzan
dc.date.accessioned2022-03-14T10:06:30Z
dc.date.available2022-03-14T10:06:30Z
dc.date.issued2008-03
dc.description.abstractMost dorsal thalamic nuclei send axons to specific areas of the neocortex and to specific sectors of the thalamic reticular nucleus; the neocortex then sends reciprocal connections back to the same thalamic nucleus, directly as well indirectly through a relay in the thalamic reticular nucleus. This can be regarded as a 'canonical' circuit of the sensory thalamus. For the pathways that link the thalamus and the hippocampal formation, only a few comparable connections have been described. The reuniens nucleus of the thalamus sends some of its major cortical efferents to the hippocampal formation. The present study shows that cells of the hippocampal formation as well as cells in the reuniens nucleus are retrogradely labelled following injections of horseradish peroxidase or fluoro-gold into the rostral part of the thalamic reticular nucleus in the rat. Within the hippocampal formation, labelled neurons were localized in the subiculum, predominantly on the ipsilateral side, with fewer neurons labelled contralaterally. Labelled neurons were seen in the hippocampal formation and nucleus reuniens only after injections made in the rostral thalamic reticular nucleus (1.6-1.8 mm caudal to bregma). In addition, the present study confirmed the presence of afferent connections to the rostral thalamic reticular nucleus from cortical (cingulate, orbital and infralimbic, retrosplenial and frontal), midline thalamic (paraventricular, anteromedial, centromedial and mediodorsal thalamic nuclei) and brainstem structures (substantia nigra pars reticularis, ventral tegmental area, periaqueductal grey, superior vestibular and pontine reticular nuclei). These results demonstrate a potential for the thalamo-hippocampal circuitry to influence the functional roles of the thalamic reticular nucleus, and show that thalamo-hippocampal connections resemble the circuitry that links the sensory thalamus and neocortex.
dc.identifier.doi10.1111/j.1469-7580.2008.00858.x
dc.identifier.eissn1469-7580
dc.identifier.issn0021-8782
dc.identifier.pubmed18221482
dc.identifier.urihttps://hdl.handle.net/11424/244054
dc.identifier.wosWOS:000253628900004
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF ANATOMY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectfluoro-gold
dc.subjecthorseradish peroxidase
dc.subjectmidline thalamic nuclei
dc.subjectretrograde transport
dc.subjectsubiculum
dc.subjectENTORHINAL CORTEX
dc.subjectVISUAL SECTOR
dc.subjectFIELD CA1
dc.subjectORGANIZATION
dc.subjectPROJECTIONS
dc.subjectNEURONS
dc.subjectAFFERENTS
dc.subjectSUBICULUM
dc.subjectFORNIX
dc.titleThe pathways connecting the hippocampal formation, the thalamic reuniens nucleus and the thalamic reticular nucleus in the rat
dc.typearticle
dspace.entity.typePublication
local.avesis.ide4c61026-62c4-4be0-b76d-4053fb1fa21b
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage256
oaire.citation.issue3
oaire.citation.startPage249
oaire.citation.titleJOURNAL OF ANATOMY
oaire.citation.volume212
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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