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Tissue factor activities of streptozotocin induced diabetic rat tissues and the effect of peanut consumption

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dc.contributor.authorYARAT, AYŞEN
dc.contributor.authorsEmekli-Alturfan, Ebru; Kasikci, Emel; Yarat, Aysen
dc.date.accessioned2022-03-12T17:32:15Z
dc.date.available2022-03-12T17:32:15Z
dc.date.issued2007
dc.description.abstractBackground Tissue factor (TF) is considered to be a major regulator of normal haemostasis and thrombosis. Circulating TF activity is suggested to be associated with diabetes mellitus. Various tissues and body fluids have TF activity. The aim of the present study was to investigate the TF activity of streptozotocin (STZ) induced diabetic rat tissues. Peanut consumption is reported to be associated with decreased risk of type 2 diabetes. Therefore, the effect of peanut consumption on the TF activity of STZ induced diabetic rat tissues, and haemostatic parameters such as protrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen levels were determined. Methods Twenty-four Wistar rats were divided into 3 groups of 8 rats each as control, STZ-induced diabetic and diabetic + peanut group. Twelve weeks later, TF activity of liver, kidney, spleen, heart, kidney, lung, pancreas and aorta and haemostatic parameters were determined. Results In the diabetic group, TF activities of liver, kidney and spleen increased (p < 0.01) whereas the TF activity of brain decreased (p < 0.01) compared to the control group. Peanut consumption in the diabetic group decreased the TF activity of spleen and aorta (p < 0.01; p < 0.05). Haemostatic parameters did not change significantly in the groups. Conclusion Elevated TF activity in diabetic rat tissues, may contribute to the increased risk of atherothrombotic disease that accompanies the diabetic complications whereas the decreased brain TF activity may be due to a different haemostatic mechanism to protect this vital organ from the diabetic status. The decreased TF activity of peanut given diabetic rat tissues might protect these tissues from the risk of thrombosis. Copyright (c) 2007 John Wiley & Sons, Ltd.
dc.identifier.doi10.1002/dmrr.757
dc.identifier.eissn1520-7560
dc.identifier.issn1520-7552
dc.identifier.pubmed17595667
dc.identifier.urihttps://hdl.handle.net/11424/228521
dc.identifier.wosWOS:000251441300009
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofDIABETES-METABOLISM RESEARCH AND REVIEWS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectpeanut
dc.subjectdiabetes
dc.subjecttissue factor
dc.subjecthaemostatic parameters
dc.subjectCORONARY-HEART-DISEASE
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectNEUROTROPHIC FACTOR
dc.subjectFACTOR EXPRESSION
dc.subjectNUT CONSUMPTION
dc.subjectRISK
dc.subjectBLOOD
dc.subjectASTROCYTES
dc.subjectFIBRINOGEN
dc.subjectMELLITUS
dc.titleTissue factor activities of streptozotocin induced diabetic rat tissues and the effect of peanut consumption
dc.typearticle
dspace.entity.typePublication
local.avesis.id34b5c9d4-ea1e-48cc-979c-06c67ca62950
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage658
oaire.citation.issue8
oaire.citation.startPage653
oaire.citation.titleDIABETES-METABOLISM RESEARCH AND REVIEWS
oaire.citation.volume23
relation.isAuthorOfPublication46115086-6b46-4ef8-aaf1-ab8eda3e917e
relation.isAuthorOfPublication.latestForDiscovery46115086-6b46-4ef8-aaf1-ab8eda3e917e

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