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The in vitro and in vivo investigation of biological activities and phenolic analysis of Helichrysum plicatum subsp. plicatum

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dc.contributor.authorŞENKARDEŞ, İSMAİL
dc.contributor.authorsTaskin, Turgut; Gezmis, Tugba; Cam, Muhammet Emin; Taskin, Duygu; Celik, Berna Ozbek; Senkardes, Ismail; Suzgec-Selcuk, Sevda
dc.date.accessioned2022-03-14T09:22:14Z
dc.date.available2022-03-14T09:22:14Z
dc.date.issued2020
dc.description.abstractIn Turkey, Helichrysum genus is represented by 26 taxa belonging to 20 species in Turkish flora of which 14 ones arc endemic to Turkey. The aerial parts of Helichrysum plicatum subsp. plicatum are used kidney stones, kidney and stomach ailments. The extraction procedures and solvents are important step in processing of bioactive constituents from the plant materials. Therefore, the aim of this study was to evaluate in vitro antioxidant, antimicrobial, anti-urease, anticholinesterase and in vivo anti-inflammatory activities of Helichrysum plicatum subsp. plicatum different extracts. In addition, the phenolic characterization of the Soxhlet and maceration methanol extracts which showed significant antioxidant, anti-urease, antimicrobial, anti-inflammatmy and anticholinesterase activities were performed by HPLC-DAD and LC-MS/MS. In the present study, the Soxhlet methanol extract exhibited strong antioxidant, antimicrobial and anticholinestemse activities than other extracts. The maceration methanol extract showed the strongest anti-urease activity. The Soxhlet methanol and maceration methanol extracts showed in vivo anti-inflammatory activities very close to each other. As a result of this study, chlorogenic acid, dicaffeoylquinic acid, luteolin, luteolin-7-O-glucoside, naringenin-O-hexoside and isoquercitrin compounds were analysed in plant. Therefore, it is thought that methanol extracts can be used as a natural source in the future for food and pharmaceutical industries.
dc.identifier.doi10.1590/s2175-97902019000418345
dc.identifier.eissn2175-9790
dc.identifier.issn1984-8250
dc.identifier.urihttps://hdl.handle.net/11424/243034
dc.identifier.wosWOS:000525404400001
dc.language.isoeng
dc.publisherUNIV SAO PAULO, CONJUNTO QUIMICAS
dc.relation.ispartofBRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHelichrysum plicatum subsp
dc.subjectplicatum
dc.subjectAnti-inflammatory
dc.subjectAnti-urease
dc.subjectAnticholinesterase
dc.subjectHPLC-DAD-MS
dc.subjectANTIOXIDANT
dc.subjectFLAVONOIDS
dc.subjectEXTRACT
dc.titleThe in vitro and in vivo investigation of biological activities and phenolic analysis of Helichrysum plicatum subsp. plicatum
dc.typearticle
dspace.entity.typePublication
local.avesis.id1199a3c3-f32b-4fd9-9154-31af3819eaec
local.import.packageSS16
local.indexed.atWOS
local.journal.articlenumbere18345
local.journal.numberofpages10
local.journal.quartileQ4
oaire.citation.titleBRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
oaire.citation.volume56
relation.isAuthorOfPublication3e59035c-d7b1-4887-b78c-2a9bc207de05
relation.isAuthorOfPublication.latestForDiscovery3e59035c-d7b1-4887-b78c-2a9bc207de05

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