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Ghrelin ameliorates pancreaticobiliary inflammation and associated remote organ injury in rats

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsKasimay, Ozgur; Iseri, Sevgin Ozlem; Barlas, Afsar; Bangir, Dilek; Yegen, Cumhur; Arbak, Serap; Yegen, Berrak C.
dc.date.accessioned2022-03-12T17:18:03Z
dc.date.available2022-03-12T17:18:03Z
dc.date.issued2006
dc.description.abstractThe present study was designed to evaluate whether ghrelin could reduce organ injury and systemic inflammation induced by pancreaticobiliary obstruction. In Sprague-Dawley rats, either the bile duct (BDL) or common pancreaticobiliary duct (PBDL) was ligated or a sham operation was applied. BDL or PBDL rats received either ghrelin (10 ng/kg) or saline intraperitoneally immediately before the surgery and once a day until the rats were decapitated at 72 h. The pancreas, liver, lung and kidney were removed for the histological analysis, and for the determination of malondialdehyde (MDA), glutathione (GSH) levels and myeloperoxidase activity (MPO). MDA and MPO levels in all the tissues, which were elevated in PBDL group (p < 0.05-0.001), were reversed back to control levels in ghrelin-treated rats. In BDL group, elevations in hepatic MDA and MPO levels (p < 0.001) were also abolished by ghrelin treatment. In contrast to saline-treated group with severe pancreatic damage, ghrelin-treated rats demonstrated a moderate pancreatic and hepatic destruction accompanied with reduced pulmonary and renal damages. The results illustrate that ghrelin protects the hepatic and pancreatic tissues, as well as remote organs against oxidative injury, by a neutrophil-dependent mechanism. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.doi10.1016/j.hepres.2006.06.009
dc.identifier.eissn1872-034X
dc.identifier.issn1386-6346
dc.identifier.pubmed16877038
dc.identifier.urihttps://hdl.handle.net/11424/227923
dc.identifier.wosWOS:000241198900003
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofHEPATOLOGY RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectmyeloperoxidase
dc.subjectcholestatic hepatic injury
dc.subjectacute pancreatitis
dc.subjectlipid peroxidation
dc.subjectOXIDATIVE STRESS
dc.subjectACYLATED PEPTIDE
dc.subjectVITAMIN-E
dc.subjectACTIVATION
dc.subjectHORMONE
dc.subjectPANCREATITIS
dc.subjectGLUTATHIONE
dc.subjectRECEPTOR
dc.subjectMYELOPEROXIDASE
dc.subjectCHOLESTASIS
dc.titleGhrelin ameliorates pancreaticobiliary inflammation and associated remote organ injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id8444b86f-5dbe-4216-b6d3-345d05f85732
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage19
oaire.citation.issue1
oaire.citation.startPage11
oaire.citation.titleHEPATOLOGY RESEARCH
oaire.citation.volume36
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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