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CARDIOVASCULAR EFFECTS OF CENTRALLY ACTIVE CHOLINOMIMETICS IN CONSCIOUS AND ANESTHETIZED RATS - THE ROLE OF AMYGDALA

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsOZKUTLU, U; COSKUN, T; ONAT, F; YEGEN, BC; OKTAY, S
dc.date.accessioned2022-03-12T16:55:52Z
dc.date.available2022-03-12T16:55:52Z
dc.date.issued1995
dc.description.abstractCentral cardiovascular effects of cholinergic agonists depend on the dose, site and mode of administration, species, and to the state of the animal. Intravenous injection of physostigmine and intracerebroventricular injection of carbachol produced presser and tachycardic responses in urethane-anesthetized rats. Both agents also elicited presser responses in conscious rats, but bradycardia occurred in the presence of anesthesia, Additionally, presser responses to physostigmine, but not to carbachol, were significantly exaggerated by urethane anesthesia. These results demonstrate that anesthesia depresses cardiovascular reflexes and the inhibitory control mechanisms on acetylcholine release from the nerve endings involved in cardiovascular regulation. The role of the central nucleus of the amygdala (CNA) was also investigated in this study. The presser effects of intracerebroventricular injection of carbachol were significantly attenuated by electrolytic ablation of the CNA, but heart rate changes were not altered both in anesthetized and conscious rats. These results indicate that the CNA plays a role in cholinergic control of blood pressure, but not in the regulation of heart rate.
dc.identifier.doi10.1016/0361-9230(95)00031-9
dc.identifier.issn0361-9230
dc.identifier.pubmed7670879
dc.identifier.urihttps://hdl.handle.net/11424/226585
dc.identifier.wosWOS:A1995RD33400003
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofBRAIN RESEARCH BULLETIN
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAMYGDALA
dc.subjectCHOLINERGIC HYPERTENSION
dc.subjectCHOLINOMIMETICS
dc.subjectPHYSOSTIGMINE
dc.subjectCARBACHOL
dc.subjectBLOOD PRESSURE
dc.subjectHEART RATE
dc.subjectANESTHESIA
dc.subjectRAT
dc.subjectNUCLEUS TRACTUS SOLITARII
dc.subjectCENTRAL NERVOUS-SYSTEM
dc.subjectCHOLINERGIC MECHANISMS
dc.subjectHYPERTENSIVE RESPONSE
dc.subjectMUSCARINIC RECEPTORS
dc.subjectBRAIN ACETYLCHOLINE
dc.subjectPRESSOR-RESPONSE
dc.subjectSTIMULATION
dc.subjectCARBACHOL
dc.subjectPHYSOSTIGMINE
dc.titleCARDIOVASCULAR EFFECTS OF CENTRALLY ACTIVE CHOLINOMIMETICS IN CONSCIOUS AND ANESTHETIZED RATS - THE ROLE OF AMYGDALA
dc.typearticle
dspace.entity.typePublication
local.avesis.idb0310fe0-7bfe-431f-9f07-7402c395b592
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage573
oaire.citation.issue6
oaire.citation.startPage569
oaire.citation.titleBRAIN RESEARCH BULLETIN
oaire.citation.volume37
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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