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Design and characterization of polycaprolactone-gelatin-graphene oxide scaffolds for drug influence on glioblastoma cells

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dc.contributor.authorATASOY, BESTE MELEK
dc.contributor.authorsUnal, Semra; Arslan, Sema; Gokce, Tilbe; Atasoy, Beste Melek; Karademir, Betul; Oktar, Faik Nuzhet; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:28:13Z
dc.date.available2022-03-12T22:28:13Z
dc.date.issued2019
dc.description.abstractThree-dimensional (3D) scaffolds that mimic in vivo tumor microenvironments can be used to study tumor response to anticancer treatments, since most preclinical combination treatment strategy for anti-glioma were evaluated with traditional 2D cell culture. In this research, the nanofiber scaffolds of polycaprolactone (PCL) containing gelatin (Gel) nano/microparticles coated with different concentrations of graphene oxide (GO) and were successfully produced by combining electrospinning and electrospraying techniques. Scanning electron microscope (SEM), Fourier-transform infrared (FT-IR) spectroscopy and mechanical testing were used to characterize the structure and properties of the composites. The results show that gelatin and graphene particles can be well dispersed in the polycaprolactone nanofiber matrix by using the combination technique of electrospinning and electrospraying. The presence of 1 wt% graphene oxide increased mechanical strength of PCL/Gel scaffold and was found to be well consistent with the drug treatments (temozolomide and bortezomib) and radiotherapy by not showing additional toxicity.
dc.identifier.doi10.1016/j.eurpolymj.2019.03.027
dc.identifier.eissn1873-1945
dc.identifier.issn0014-3057
dc.identifier.urihttps://hdl.handle.net/11424/235296
dc.identifier.wosWOS:000471736400018
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofEUROPEAN POLYMER JOURNAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNanocomposite
dc.subjectElectrospinning
dc.subjectElectrospraying
dc.subjectGraphene oxide, glioblastoma cells
dc.subject3-DIMENSIONAL SCAFFOLDS
dc.subjectELECTROSPUN NANOFIBERS
dc.subjectFABRICATION
dc.subjectCHITOSAN
dc.subjectBORTEZOMIB
dc.subjectMIGRATION
dc.titleDesign and characterization of polycaprolactone-gelatin-graphene oxide scaffolds for drug influence on glioblastoma cells
dc.typearticle
dspace.entity.typePublication
local.avesis.id86cfb756-2f8d-4540-a3be-9c19a44fbcbe
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
local.journal.quartileQ1
oaire.citation.endPage165
oaire.citation.startPage157
oaire.citation.titleEUROPEAN POLYMER JOURNAL
oaire.citation.volume115
relation.isAuthorOfPublication22ce1b48-93da-4e88-a61e-be24b5e6122a
relation.isAuthorOfPublication.latestForDiscovery22ce1b48-93da-4e88-a61e-be24b5e6122a

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