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The functional assessment of autotransplanted splenic tissue by its capacity to remove oxidatively modified erythrocytes

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dc.contributor.authorYALÇIN, AHMET SUHA
dc.contributor.authorsHaklar, G.; Demirel, M.; Peker, O.; Eskitürk, A.; Işgör, A.; Söyletir, G.; Yalçin, A. S.
dc.date.accessioned2022-03-15T11:10:22Z
dc.date.available2022-03-15T11:10:22Z
dc.date.issued1997
dc.description.abstractFree radicals and reactive oxygen species have been implicated in the pathogenesis of a variety of hematologic diseases and erythrocyte aging. Aged erythrocytes are removed from the circulation primarily by the spleen. In this study, we aimed to determine the functional effectiveness of autotransplanted splenic tissue by its capacity to remove oxidatively modified erythrocytes from the circulation. Our experimental model in rats includes splenectomy with autotransplantation of 80% of the excised splenic tissue into the omental pouch. In this model, free radical damage was estimated by different parameters of lipid peroxidation such as carbonyl content and thiobarbituric acid reactive substances (TBARS), together with Heinz body formation. Our results have shown that splenic autotransplantation was effective in removing oxidatively modified, aged erythrocytes from the circulation.
dc.identifier.doi10.1016/s0009-8981(96)06455-8
dc.identifier.issn0009-8981
dc.identifier.pubmedPMID: 9074816
dc.identifier.urihttps://hdl.handle.net/11424/248665
dc.language.isoeng
dc.relation.ispartofClinica Chimica Acta; International Journal of Clinical Chemistry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnimals
dc.subjectMale
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectLipid Peroxidation
dc.subjectTransplantation, Autologous
dc.subjectHalf-Life
dc.subjectRegeneration
dc.subjectFree Radicals
dc.subjectErythrocyte Aging
dc.subjectSpleen
dc.titleThe functional assessment of autotransplanted splenic tissue by its capacity to remove oxidatively modified erythrocytes
dc.typearticle
dspace.entity.typePublication
local.avesis.ide6753205-f6ae-4557-bbd8-eb41496dd023
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage208
oaire.citation.startPage201
oaire.citation.titleClinica Chimica Acta; International Journal of Clinical Chemistry
oaire.citation.volume2
relation.isAuthorOfPublication7a2bc583-aab6-43e7-9cc3-0d7a60773409
relation.isAuthorOfPublication.latestForDiscovery7a2bc583-aab6-43e7-9cc3-0d7a60773409

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