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Effect of ELF-EMF on K562 cell differentiation in the presence or absence of quercetin and heat-shock

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dc.contributor.authorGARİP, GÜNSELİ AYŞE
dc.contributor.authorsGarip-Inhan, A.; Isal-Tugut, I.; Kalkan, M. T.
dc.date.accessioned2022-03-12T17:32:56Z
dc.date.available2022-03-12T17:32:56Z
dc.date.issued2007
dc.description.abstractExtremely low frequency electromagnetic fields (ELF-EMF) are known to produce a variety of biological effects although the underlying mechanism has not been elucidated yet. The present study aimed to investigate the effect of ELF-EMF on K562 cells induced to differentiate with or without quercetin with application of heat-shock. 50Hz ELF-EW was applied at three (1mT,5mT,10mT) field intensities. Quercetin is,flavonoid known to have anti-tumorigenic and anti-proliferative properties. Heat-shock was applied since it has been shown that quercetin down-regulates but ELF-EMF increases heat-shock protein levels. Results of this study show that ELF-EMF increases differentiation of untreated K562 cells at low field intensities in accordance with the window effect of these fields. Heat-shock abolishes this increase. Heat-shock also decreases the %differentiation of quercetin induced cells. However it has no effect on quercetin induced ELF-EMF exposed cells implying a protective effect of ELF-EMF These results prompted us to hypothesize that these fields can act antagonistically with heat-shock under certain conditions.
dc.identifier.doi10.1080/13102818.2007.10817441
dc.identifier.eissn1314-3530
dc.identifier.issn1310-2818
dc.identifier.urihttps://hdl.handle.net/11424/228728
dc.identifier.wosWOS:000254704300011
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofBIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectELF-EMF
dc.subjectquercetin
dc.subjectheat-shock
dc.subjectdifferentiation
dc.subjectK562
dc.subjectGENE-EXPRESSION
dc.subjectFLAVONOIDS
dc.subjectINDUCTION
dc.titleEffect of ELF-EMF on K562 cell differentiation in the presence or absence of quercetin and heat-shock
dc.typearticle
dspace.entity.typePublication
local.avesis.id976407db-0cf8-48ee-b5aa-f3c2728f9f06
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages4
oaire.citation.endPage185
oaire.citation.issue2
oaire.citation.startPage182
oaire.citation.titleBIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
oaire.citation.volume21
relation.isAuthorOfPublication4e6e5b70-56a5-4519-bbe7-fde9a6ec4775
relation.isAuthorOfPublication.latestForDiscovery4e6e5b70-56a5-4519-bbe7-fde9a6ec4775

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