Publication:
Endocrine disrupting chemicals and bone

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dc.contributor.authorDEMİRCİOĞLU, SERAP
dc.contributor.authorsTuran, Serap
dc.date.accessioned2022-03-12T22:55:20Z
dc.date.available2022-03-12T22:55:20Z
dc.date.issued2021
dc.description.abstractEndocrine-disrupting chemicals (EDCs) are defined as chemicals that interfere with the function of the endocrine system. EDCs exert their hormonal effects through several mechanisms; modulating hormone receptors or changing metabolism of different hormones. EDCs also influence multiple signalling pathways while effecting the hormonal systems and possess complex dose eresponse curves. EDCs can exert deleterious effects on bone tissue through changing bone modelling and remodelling via altering bone paracrine hormone synthesis, the release of systemic hormones, cytokines, chemokines and growth factors, and effecting stem cell fate, as well as bone marrow mesenchymal stem cell differentiation. Evidence is accumulating of the bone disrupting effect of different groups of EDCs, such as; the perfluoroalkyl substances, the phthalate esters, the bisphenol A, the organotin compounds, the alkylphenols and the dioxin and dioxin-like compounds. This review highlights the recent discoveries of the effects of commonly found environmental chemicals on bone from basic molecular findings to clinical implications. (C) 2021 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.beem.2021.101495
dc.identifier.eissn1532-1908
dc.identifier.issn1521-690X
dc.identifier.pubmed33618984
dc.identifier.urihttps://hdl.handle.net/11424/236720
dc.identifier.wosWOS:000705235700010
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofBEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectendocrine disrupting chemicals
dc.subjectbone
dc.subjectperfluoroalkyl substances
dc.subjectphthalate esters
dc.subjectdioxins
dc.subjectbisphenols
dc.subjectURINARY PHTHALATE METABOLITES
dc.subjectN-BUTYL PHTHALATE
dc.subjectHUMAN BREAST-MILK
dc.subjectMINERAL DENSITY
dc.subjectOSTEOCLAST DIFFERENTIATION
dc.subjectPERFLUOROALKYL SUBSTANCES
dc.subjectBISPHENOL-A
dc.subjectPPAR-GAMMA
dc.subjectDI(2-ETHYLHEXYL) PHTHALATE
dc.subjectPERFLUOROOCTANE SULFONATE
dc.titleEndocrine disrupting chemicals and bone
dc.typearticle
dspace.entity.typePublication
local.avesis.ida8429411-b407-4af8-a6ad-9d642ab52c8e
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber101495
local.journal.numberofpages16
oaire.citation.issue5
oaire.citation.titleBEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
oaire.citation.volume35
relation.isAuthorOfPublication1c59e516-384a-4161-af91-3c3088f49d21
relation.isAuthorOfPublication.latestForDiscovery1c59e516-384a-4161-af91-3c3088f49d21

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