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Histopathological changes and tumour necrosis factor-alpha, transforming growth factor-beta and tenascin expression in patients with primary type I membranoproliferative glomerulonephritis in remission

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dc.contributor.authorARIKAN, İZZET HAKKI
dc.contributor.authorsArikan, Hakki; Koc, Mehmet; Cakalagaoglu, Fulya; Tuglular, Serhan; Ozener, Cetin; Akoglu, Emel
dc.date.accessioned2022-03-12T17:37:09Z
dc.date.available2022-03-12T17:37:09Z
dc.date.issued2009
dc.description.abstractAim: Primary type I membranoproliferative glomerulonephritis (MPGN) is a rare cause of glomerular disease with a high relapse rate and poor prognosis. The aim of this study was: (i) to evaluate the histopathological findings associated with remission; and (ii) to document the possible clinical and histopathological factors predicting relapses. Methods: Eleven type I MPGN patients (five men, six women; mean age, 38.8 +/-13.5 years) who were in remission for at least 1 year after the cessation of immunosuppressive drugs were re-biopsied. The intensity of immunostaining for tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta 1, and tenascin was graded from 0 (no staining) to 3+ (maximum staining). Results: Mean baseline mesangial cellularity score and tubulointerstitial infiltration score were reduced and mesangial matrix expansion score was increased at protocol re-biopsies compared to baseline. The glomerular and tubulointerstitial staining scores for TGF-beta 1 and tenascin were higher than that of baseline. Reduced tubulointerstitial TNF-alpha expression was found in re-biopsy specimens compared to baseline. Patients have been followed for a mean time of 51.5 +/- 22.2 months after the protocol biopsy. Eight patients had a relapse. Mesangial cellularity score and glomerular tenascin expression at re-biopsy specimens were higher in relapsed patients compared to those without a relapse. Conclusion: Our study shows that mesangial cellularity and tubulointerstitial cell infiltration are reducing whereas mesangial matrix expansion, glomerular and tubulointerstitial TGF-beta 1 and tenascin expression are increasing with remission. The higher mesangial cell proliferation and glomerular tenascin scores in remission are associated with the development of relapse.
dc.identifier.doi10.1111/j.1440-1797.2008.01048.x
dc.identifier.eissn1440-1797
dc.identifier.issn1320-5358
dc.identifier.pubmed19298642
dc.identifier.urihttps://hdl.handle.net/11424/229350
dc.identifier.wosWOS:000264785200012
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofNEPHROLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjecthistopathology
dc.subjectprimary membranoproliferative glomerulonephritis
dc.subjectre-biopsy
dc.subjectrelapse
dc.subjecttenascin
dc.subjectRAT MESANGIAL CELLS
dc.subjectEXTRACELLULAR-MATRIX
dc.subjectPATHOLOGICAL CONDITIONS
dc.subjectEPITHELIAL-CELLS
dc.subjectIGA NEPHROPATHY
dc.subjectTNF-ALPHA
dc.subjectTHERAPY
dc.subjectPROLIFERATION
dc.subjectCHILDREN
dc.titleHistopathological changes and tumour necrosis factor-alpha, transforming growth factor-beta and tenascin expression in patients with primary type I membranoproliferative glomerulonephritis in remission
dc.typearticle
dspace.entity.typePublication
local.avesis.id29191abc-0649-4e18-a16c-df1be1f4ee3d
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
oaire.citation.endPage226
oaire.citation.issue2
oaire.citation.startPage219
oaire.citation.titleNEPHROLOGY
oaire.citation.volume14
relation.isAuthorOfPublication1fe3028b-011e-403a-ac08-1932d177a065
relation.isAuthorOfPublication.latestForDiscovery1fe3028b-011e-403a-ac08-1932d177a065

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