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Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation

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dc.contributor.authorERTAŞ, BÜŞRA
dc.contributor.authorŞEN, ALİ
dc.contributor.authorAKAKIN, DİLEK
dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsKanpalta Mustafaoğlu F., Ertaş B., Şen A., Akakın D., Şener G., Ercan F.
dc.date.accessioned2022-12-27T17:13:51Z
dc.date.available2022-12-27T17:13:51Z
dc.date.issued2022-12-02
dc.description.abstractObjective: Obesity is associated with many diseases, including urinary system disorders such as chronic kidney disease and overactive bladder syndrome. Myrtus communis L. (MC) extract has been reported to have antioxidant and anti-inflammatory effects. The aim of this study was to investigate the protective effects of MC extract on high-fat diet (HFD)-induced kidney and bladder damage. Materials and Methods: Wistar albino male rats were divided into three experimental groups: control, HFD and HFD+MC. Experimental groups were fed a standard diet (control group) or HFD (HFD and HFD+MC groups) for 16 weeks. MC extract (100 mg/kg) was administered to the HFD+MC group orally during the last 4 weeks (5 days/week) of the experiment. Highdensity lipoprotein, total cholesterol, triglyceride and leptin levels were measured in blood serum. Tissue malondialdehyde (MDA), glutathione (GSH), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and myeloperoxidase (MPO) levels were evaluated biochemically. Kidney and bladder morphology, NADPH oxidase-2 (NOX-2) and nuclear factor-kappa B (NF-ҡB)-positive and apoptotic cells were evaluated histologically. Results: Lipid profiles altered and leptin levels increased in blood serum. MDA, 8-OHdG and MPO levels increased and GSH level decreased in kidney and bladder in the HFD group. Moreover, degenerated kidney and bladder morphology, increased NOX-2 and NF-ҡB-positive and apoptotic cells were observed in this group. All of these biochemical and histological parameters were ameliorated in the HFD+MC group. Conclusion: HFD-induced obesity causes kidney and bladder damage by oxidative and inflammatory processes. MC extract may reduce oxidative stress and inflammation and play a protective role in obesity-related kidney and bladder damage.
dc.identifier.citationKanpalta Mustafaoğlu F., Ertaş B., Şen A., Akakın D., Şener G., Ercan F., "Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation", European Journal of Biology, cilt.81, sa.2, ss.1-14, 2022
dc.identifier.doi10.26650/eurjbiol.2022.1111191
dc.identifier.endpage14
dc.identifier.issn2602-2575
dc.identifier.issue2
dc.identifier.startpage1
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/7ae9bead-5368-4fb7-88ba-02bd77e5af9d/file
dc.identifier.urihttps://hdl.handle.net/11424/284340
dc.identifier.volume81
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Biology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectHistoloji-Embriyoloji
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHistology and Embryology
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectCELL BIOLOGY
dc.subjectGenel Sağlık Meslekleri
dc.subjectPatofizyoloji
dc.subjectTemel Bilgi ve Beceriler
dc.subjectDeğerlendirme ve Teşhis
dc.subjectDahiliye
dc.subjectAile Sağlığı
dc.subjectTıp (çeşitli)
dc.subjectGenel Tıp
dc.subjectHücre Biyolojisi
dc.subjectYaşam Bilimleri
dc.subjectGeneral Health Professions
dc.subjectPathophysiology
dc.subjectFundamentals and Skills
dc.subjectAssessment and Diagnosis
dc.subjectInternal Medicine
dc.subjectFamily Practice
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectCell Biology
dc.subjectLife Sciences
dc.subjectHigh fat diet
dc.subjectMyrtus communis L. extract
dc.subjectkidney
dc.subjectbladder
dc.subjectoxidative stress
dc.subjectinflammation
dc.titleMyrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation
dc.typearticle
dspace.entity.typePublication
local.avesis.id7ae9bead-5368-4fb7-88ba-02bd77e5af9d
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relation.isAuthorOfPublication.latestForDiscovery864e7cb0-b39f-48bb-a546-ee65ffc807b2

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