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Reversal of valproate-induced major salivary gland changes by moringa oleifera extract in rats

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dc.contributor.authorYARAT, AYŞEN
dc.contributor.authorsÇergel E., Alev-Tuzuner B., Turkyılmaz Mutlu I. B., Oktay N., Magaji U. F., Sacan O., Yanardag R., Yarat A.
dc.date.accessioned2024-04-22T16:27:04Z
dc.date.available2024-04-22T16:27:04Z
dc.date.issued2024-03-01
dc.description.abstractThis study aimed to explore the potential protective impacts ofMoringa oleiferaextract on major alteration in salivary glands of rats exposed to sodium valproate (VA). Groups were defined as control, control+moringa extract, sodium valproate, and sodium valproate+moringa extract. Antioxidant and oxidant status, activities of digestive and metabolic enzymes were examined. VA treatment led to various biochemical changes in the salivary glands, including decreased levels of antioxidants like glutathione, glutathione-S-transferase, and superoxide dismutase (except for sublingual superoxide dismutase). Conversely, a decrease in alpha-amylase, alkaline and acid phosphatase, lactate dehydrogenase, protease, and maltase activities were observed. The study also demonstrated that VA induces oxidative stress, increases lipid peroxidation, sialic acid, and nitric oxide levels in the salivary glands. Total oxidant capacity was raised in all glands except in the sublingual gland. The electrophoretic patterns of proteins were similar.Moringa oleiferaextract exhibited protective properties, reversing these VA-induced biochemical changes due to its antioxidant and therapeutic attributes. This research suggests that moringa extract might serve as an alternative treatment approach for individuals using VA and experiencing salivary gland issues, although further research is necessary to confirm these findings in human subjects.
dc.identifier.citationÇergel E., Alev-Tuzuner B., Turkyılmaz Mutlu I. B., Oktay N., Magaji U. F., Sacan O., Yanardag R., Yarat A., "REVERSAL OF VALPROATE-INDUCED MAJOR SALIVARY GLAND CHANGES BY MORINGA OLEIFERA EXTRACT IN RATS", CHEMISTRY AND BIODIVERSITY, cilt.12, sa.x, ss.1-9, 2024
dc.identifier.doi10.1002/cbdv.202301959
dc.identifier.endpage9
dc.identifier.issn1612-1872
dc.identifier.issuex
dc.identifier.startpage1
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/cbdv.202301959
dc.identifier.urihttps://hdl.handle.net/11424/296654
dc.identifier.volume12
dc.language.isoeng
dc.relation.ispartofCHEMISTRY AND BIODIVERSITY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSağlık Bilimleri
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectClinical Medicine (MED)
dc.titleReversal of valproate-induced major salivary gland changes by moringa oleifera extract in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id529e6f1e-17e3-4773-9c31-6b757b3ea577
relation.isAuthorOfPublication46115086-6b46-4ef8-aaf1-ab8eda3e917e
relation.isAuthorOfPublication.latestForDiscovery46115086-6b46-4ef8-aaf1-ab8eda3e917e

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