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The effect of magnesium and vitamin E pre-treatments on irradiation-induced oxidative injury of cardiac and pulmonary tissues in rats: a randomized experimental study

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dc.contributor.authorATASOY, BESTE MELEK
dc.contributor.authorsAtasoy, Beste M.; Ozgen, Zerrin; Bostanci, Korkut; Yuksel, Meral; Ozen, Zeynep; Ibrahimov, Roman; Abacioglu, Ufuk
dc.date.accessioned2022-03-12T18:05:37Z
dc.date.available2022-03-12T18:05:37Z
dc.date.issued2012
dc.description.abstractObjective: The aim of this study was to investigate the effect of pre-treatment with the free radical scavenging molecules, magnesium and vitamin E, on lipid peroxidation to limit radiation-induced heart and lung injury. Methods: Female Sprague-Dawley rats were divided into 4 groups by a simple randomization method as saline-treated control (n=4), saline-treated irradiated (IR; n=6), magnesium sulphate-treated irradiation (IR) (Mg+IR; n=6) and vitamin E-treated IR (vit E+IR; n=6), respectively. The animals were given either saline, Mg (600mg/kg/day) or vit E (100 mg/kg/day) intraperitoneally for five days prior to irradiation. Twelve hours after the fifth injection, animals in irradiation groups were irradiated to 20 Gy using 6 MV photons in linear accelerator. Twenty-four hours later cardiac and lung tissue samples were obtained for determination of myeloperoxidase activity (MPO), malondialdehyde (MDA) levels, and luminol and lucigenin levels measured by chemiluminescence (CL) methods. Results: No significant changes were observed between cardiac and pulmonary MDA and CL results of the experimental groups. However, cardiac and pulmonary MPO activities in the saline-treated IR group were increased as compared to control group (p<0.05 for all), while in the Mg-pretreated and vit E pretreated groups neutrophil infiltration was reduced, reaching to statistical significance only in the Mg-pretreated group (p<0.05). Conclusion: Prophylactic use of magnesium sulfate has limited the infiltration of neutrophils to both the cardiac and pulmonary tissues at the early 24 h of irradiation. However, how limiting neutrophils as the sources of free radicals and inflammatory mediators would alter oxidative stress of heart and lung tissues in the long-term is not clear yet. (Anadolu Kardiyol Derg 2012; 12: 508-14)
dc.identifier.doi10.5152/akd.2012.159
dc.identifier.eissn2149-2271
dc.identifier.issn2149-2263
dc.identifier.pubmed22721827
dc.identifier.urihttps://hdl.handle.net/11424/230732
dc.identifier.wosWOS:000308575800011
dc.language.isoeng
dc.publisherTURKISH SOC CARDIOLOGY
dc.relation.ispartofANATOLIAN JOURNAL OF CARDIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHeart
dc.subjectirradiation
dc.subjectlung
dc.subjectmagnesium
dc.subjectradioprotection
dc.subjectvitamin E
dc.subjectBREAST-CANCER
dc.subjectHEART-DISEASE
dc.subjectREACTIVE OXYGEN
dc.subjectFOLLOW-UP
dc.subjectIN-VITRO
dc.subjectRADIATION
dc.subjectRADIOTHERAPY
dc.subjectAMIFOSTINE
dc.subjectMYELOPEROXIDASE
dc.subjectSURVEILLANCE
dc.titleThe effect of magnesium and vitamin E pre-treatments on irradiation-induced oxidative injury of cardiac and pulmonary tissues in rats: a randomized experimental study
dc.typearticle
dspace.entity.typePublication
local.avesis.ida744a64a-38a5-4d90-8413-e9a663d49600
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage514
oaire.citation.issue6
oaire.citation.startPage508
oaire.citation.titleANATOLIAN JOURNAL OF CARDIOLOGY
oaire.citation.volume12
relation.isAuthorOfPublication22ce1b48-93da-4e88-a61e-be24b5e6122a
relation.isAuthorOfPublication.latestForDiscovery22ce1b48-93da-4e88-a61e-be24b5e6122a

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