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Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis - An international cohort study

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dc.contributor.authorDUMAN, DENİZ
dc.contributor.authorsDemcsak, Alexandra; Soos, Alexandra; Kincses, Lilla; Capunge, Ines; Minkov, Georgi; Kovacheva-Slavova, Mila; Nakov, Radislav; Wu, Dong; Huang, Wei; Xia, Qing; Deng, Lihui; Hollenbach, Marcus; Schneider, Alexander; Hirth, Michael; Ioannidis, Orestis; Vincze, Aron; Bajor, Judit; Sarlos, Patricia; Czako, Laszlo; Illes, Dora; Izbeki, Ferenc; Gajdan, Laszlo; Papp, Maria; Hamvas, Jozsef; Varga, Marta; Kanizsai, Peter; Bona, Erno; Miko, Alexandra; Vancsa, Szilard; Juhasz, Mark Felix; Ocskay, Klementina; Darvasi, Erika; Miklos, Emoke; Eross, Balint; Szentesi, Andrea; Parniczky, Andrea; Casadei, Riccardo; Ricci, Claudio; Ingaldi, Carlo; Mastrangelo, Laura; Jovine, Elio; Cennamo, Vincenzo; Marino, Marco V.; Barauskas, Giedrius; Ignatavicius, Povilas; Pelaez-Luna, Mario; Rios, Andrea Soriano; Turcan, Svetlana; Tcaciuc, Eugen; Malecka-Panas, Ewa; Zatorski, Hubert; Nunes, Vitor; Gomes, Antonio; Goncalves, Tiago Curdia; Freitas, Marta; Constantino, Julio; Sa, Milene; Pereira, Jorge; Mateescu, Bogdan; Constantinescu, Gabriel; Sandru, Vasile; Negoi, Ionut; Ciubotaru, Cezar; Negoita, Valentina; Bunduc, Stefania; Gheorghe, Cristian; Barbu, Sorin; Tantau, Alina; Tantau, Marcel; Dumitru, Eugen; Suceveanu, Andra Iulia; Tocia, Cristina; Gherbon, Adriana; Litvin, Andrey; Shirinskaya, Natalia; Rabotyagova, Yliya; Bezmarevic, Mihailo; Hegyi, Peter Jeno; Han, Jimin; Rodriguez-Oballe, Juan Armando; Salas, Isabel Miguel; Comas, Eva Pijoan; de la Iglesia Garcia, Daniel; Cuadrado, Andrea Jardi; Castineira, Adriano Quiroga; Chang, Yu-Ting; Chang, Ming-Chu; Kchaou, Ali; Tlili, Ahmed; Kacar, Sabite; Gokbulut, Volkan; Duman, Deniz; Kani, Haluk Tarik; Altintas, Engin; Chooklin, Serge; Chuklin, Serhii; Gougol, Amir; Papachristou, George; Hegyi, Peter
dc.date.accessioned2022-03-14T09:27:48Z
dc.date.available2022-03-14T09:27:48Z
dc.date.issued2020-10
dc.description.abstractBackground: Acid suppressing drugs (ASD) are generally used in acute pancreatitis (AP); however, large cohorts are not available to understand their efficiency and safety. Therefore, our aims were to evaluate the association between the administration of ASDs, the outcome of AP, the frequency of gastrointestinal (GI) bleeding and GI infection in patients with AP. Methods: We initiated an international survey and performed retrospective data analysis on AP patients hospitalized between January 2013 and December 2018. Results: Data of 17,422 adult patients with AP were collected from 59 centers of 23 countries. We found that 23.3% of patients received ASDs before and 86.6% during the course of AP. ASDs were prescribed to 57.6% of patients at discharge. ASD administration was associated with more severe AP and higher mortality. GI bleeding was reported in 4.7% of patients, and it was associated with pancreatitis severity, mortality and ASD therapy. Stool culture test was performed in 6.3% of the patients with 28.4% positive results. Clostridium difficile was the cause of GI infection in 60.5% of cases. Among the patients with GI infections, 28.9% received ASDs, whereas 24.1% were without any acid suppression treatment. GI infection was associated with more severe pancreatitis and higher mortality. Conclusions: Although ASD therapy is widely used, it is unlikely to have beneficial effects either on the outcome of AP or on the prevention of GI bleeding during AP. Therefore, ASD therapy should be substantially decreased in the therapeutic management of AP. (C) 2020 IAP and EPC. Published by Elsevier B.V.
dc.identifier.doi10.1016/j.pan.2020.08.009
dc.identifier.eissn1424-3911
dc.identifier.issn1424-3903
dc.identifier.pubmed32948430
dc.identifier.urihttps://hdl.handle.net/11424/243152
dc.identifier.wosWOS:000579864600011
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofPANCREATOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcid suppressing drug
dc.subjectGastrointestinal bleeding
dc.subjectGastrointestinal infection
dc.subjectAcute pancreatitis
dc.subjectProton pump inhibitor
dc.subjectPROTON-PUMP INHIBITORS
dc.subjectRISK
dc.subjectMANAGEMENT
dc.subjectASSOCIATION
dc.subjectCANCER
dc.subjectDRUGS
dc.titleAcid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis - An international cohort study
dc.typearticle
dspace.entity.typePublication
local.avesis.id729fa811-82eb-4508-ad1b-5ba1f04e0947
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
local.journal.quartileQ2
oaire.citation.endPage1331
oaire.citation.issue7
oaire.citation.startPage1323
oaire.citation.titlePANCREATOLOGY
oaire.citation.volume20
relation.isAuthorOfPublicationfbd7db24-b703-41cb-8619-c66129ba9556
relation.isAuthorOfPublication.latestForDiscoveryfbd7db24-b703-41cb-8619-c66129ba9556

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