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Effects of some lubricants and evaluation of compression parameters on directly compressible powders

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dc.contributor.authorUĞURLU, TİMUÇİN
dc.contributor.authorsUgurlu, Timucin; Halacoglu, Mekin Doga
dc.date.accessioned2022-03-13T12:44:43Z
dc.date.available2022-03-13T12:44:43Z
dc.date.issued2014
dc.description.abstractThe objective of this study was to investigate the effects of conventional lubricants including a new candidate lubricant Hexagonal boron nitride (HBN) on direct compression powders. Lubricants such as magnesium stearate, glyceryl behenate, stearic acid, talc and polyethylene glycol(6000) were studied in this article. Tablets were manufactured on an instrumented tablet press with various lubricant concentrations. Bulk and tapped densities, and Carr's index parameters were calculated for powders. Tensile strength, cohesion index, lower punch ejection force and lubricant effectiveness values were investigated for tablets. The deformation mechanisms of tablets were studied during compression from the Heckel plots with or without lubricants. Powders formulated with MGST and HBN showed better flow properties based on Carr's index. MGST was found to be the most effective lubricant based on lubricant effectiveness for tablets. HBN was found very close to MGST with the same concentrations. Other lubricants showed less effectiveness than that of MGST and HBN. It is observed that an increase in the concentration of HBN leads to decreased tensile strength and cohesion index values because of its surface-covering property. Despite covering property, HBN had no significant effect on disintegration time. Based on the Heckel plots at the level of 1%, HBN showed the most pronounced plastic character.
dc.identifier.doi10.3109/10837450.2013.784443
dc.identifier.eissn1097-9867
dc.identifier.issn1083-7450
dc.identifier.pubmed23590449
dc.identifier.urihttps://hdl.handle.net/11424/237630
dc.identifier.wosWOS:000328136500014
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofPHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCohesion index
dc.subjectdirect compression
dc.subjecthexagonal boron nitride
dc.subjectlubricants
dc.subjectlubricant effectiveness
dc.subjectBORON-NITRIDE NANOTUBES
dc.subjectCOMPACTION PROPERTIES
dc.titleEffects of some lubricants and evaluation of compression parameters on directly compressible powders
dc.typearticle
dspace.entity.typePublication
local.avesis.id77d50947-88bf-4e10-9cbf-9457cc91b32c
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage354
oaire.citation.issue3
oaire.citation.startPage347
oaire.citation.titlePHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
oaire.citation.volume19
relation.isAuthorOfPublication0f48a4ac-c964-4c96-ab96-c6a811cbbbf3
relation.isAuthorOfPublication.latestForDiscovery0f48a4ac-c964-4c96-ab96-c6a811cbbbf3

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