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The provisional OMERACT ultrasonography score for giant cell arteritis

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dc.contributor.authorİNANÇ, GÜZİDE NEVSUN
dc.contributor.authorsDejaco C., Ponte C., Monti S., Rozza D., Scirè C. A., Terslev L., Bruyn G. A., Boumans D., Hartung W., Hočevar A., et al.
dc.date.accessioned2023-03-28T05:55:56Z
dc.date.available2023-03-28T05:55:56Z
dc.date.issued2023-04-01
dc.description.abstractObjectives To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from -1.19 to -2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corr coeff 0.37-0.48). Conclusion We developed a provisional OGUS for potential use in clinical trials.
dc.identifier.citationDejaco C., Ponte C., Monti S., Rozza D., Scirè C. A., Terslev L., Bruyn G. A., Boumans D., Hartung W., Hočevar A., et al., "The provisional OMERACT ultrasonography score for giant cell arteritis", Annals of the Rheumatic Diseases, cilt.82, sa.4, ss.556-564, 2023
dc.identifier.doi10.1136/ard-2022-223367
dc.identifier.endpage564
dc.identifier.issn0003-4967
dc.identifier.issue4
dc.identifier.startpage556
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85144887883&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/287901
dc.identifier.volume82
dc.language.isoeng
dc.relation.ispartofAnnals of the Rheumatic Diseases
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectİmmünoloji ve Romatoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectImmunology and Rheumatology
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectİmmünoloji
dc.subjectALERJİ
dc.subjectROMATOLOJİ
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectIMMUNOLOGY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectALLERGY
dc.subjectRHEUMATOLOGY
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectRomatoloji
dc.subjectİmmünoloji ve Alerji
dc.subjectGenel Biyokimya, Genetik ve Moleküler Biyoloji
dc.subjectRheumatology
dc.subjectImmunology and Allergy
dc.subjectImmunology
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectgiant cell arteritis
dc.subjectultrasonography
dc.subjectoutcome assessment
dc.subjecthealth care
dc.subjectsystemic vasculitis
dc.subjectULTRASOUND
dc.subjectTOCILIZUMAB
dc.subjectSONOGRAPHY
dc.subjectTRIAL
dc.subjectoutcome assessment, health care
dc.titleThe provisional OMERACT ultrasonography score for giant cell arteritis
dc.typearticle
dspace.entity.typePublication
local.avesis.id1501cb11-d19e-4ff8-847d-ba1f98249e70
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationc963a17b-4775-4dd7-8db7-ea072cc49ef1
relation.isAuthorOfPublication.latestForDiscoveryc963a17b-4775-4dd7-8db7-ea072cc49ef1

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