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Flow cytometric DNA studies and AgNOR counts in patients with transitional cell carcinoma of the bladder

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dc.contributor.authorÇELİKEL, ÇİĞDEM
dc.contributor.authorsÇELİKEL Ç., Dillioglugil O., Turkeri L., Basaran M., Yalciner A., Kullu S., Akdas A.
dc.date.accessioned2023-01-23T07:38:43Z
dc.date.available2023-01-23T07:38:43Z
dc.date.issued1995-01-01
dc.description.abstractFlow cytometry appears to be a promising diagnostic method which may influence the therapeutic approach to transitional cell carcinoma (TCC) of the bladder. The number of silver-stained nuclear organizer regions (AgNORs) seems to correlate with the growth fractions of the cells. In this study, we report the results of combined flow cytometric analysis and AgNOR in 37 patients with TCC of the bladder. A positive correlation was observed in the histological grade, stage and growth pattern in relation to the ploidy of tumors. There were statistically significant differences among the mean AgNOR counts of the different groups as defined by DNA content, histological grade, growth pattern and disease outcome. In different stage groups, the AgNOR counts were related both to recurrence and progression. It was concluded that AgNOR counts performed on routine formalin-fixed paraffin sections furnish significant kinetic information. According to our preliminary results AgNOR counts and the DNA content of the tumors should also be measured to decide on more aggressive treatment in some cases.
dc.identifier.citationÇELİKEL Ç., Dillioglugil O., Turkeri L., Basaran M., Yalciner A., Kullu S., Akdas A., "Flow cytometric DNA studies and AgNOR counts in patients with transitional cell carcinoma of the bladder", European Urology, cilt.28, sa.2, ss.152-157, 1995
dc.identifier.doi10.1159/000475041
dc.identifier.endpage157
dc.identifier.issn0302-2838
dc.identifier.issue2
dc.identifier.startpage152
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0029153318&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/285710
dc.identifier.volume28
dc.language.isoeng
dc.relation.ispartofEuropean Urology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectNefroloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectNephrology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectUROLOGY & NEPHROLOGY
dc.subjectÜroloji
dc.subjectUrology
dc.subjectAgNOR
dc.subjectBladder neoplasms
dc.subjectDNA cytometry
dc.subjectFlow cytometry
dc.titleFlow cytometric DNA studies and AgNOR counts in patients with transitional cell carcinoma of the bladder
dc.typearticle
dspace.entity.typePublication
local.avesis.id5230e496-71b2-4081-bbee-662b2fe3aa75
local.indexed.atPUBMED
local.indexed.atSCOPUS
local.indexed.atWOS
relation.isAuthorOfPublicationbc2327ed-471c-42da-86dd-cef77979cda2
relation.isAuthorOfPublication.latestForDiscoverybc2327ed-471c-42da-86dd-cef77979cda2

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