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Repair of critical size defects using bioactive glass seeded with adipose-derived mesenchymal stem cells

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dc.contributor.authorYILMAZ, BETÜL
dc.contributor.authorsSacak, Bulent; Certel, Furkan; Akdeniz, Zeynep D.; Karademir, Betul; Ercan, Feriha; Ozkan, Naziye; Akpinar, Ihsan Nuri; Celebiler, Ozhan
dc.date.accessioned2022-03-12T20:31:54Z
dc.date.available2022-03-12T20:31:54Z
dc.date.issued2017
dc.description.abstractBioactive glass has been demonstrated as a biocompatible bone substitute. However bone healing process can be prolonged due to late resorption of the material. Adipose derived stem cells (ASC) have osteogenic differentiation potential and hence can be a cell source for bone regeneration. The aim of this study was to test whether combination of bioactive glass with ASCs would enhance bone regeneration. Following creation of critical sized defects on the calvaria of 32 Wistar rats, the animals were randomly divided into four groups: Group C (control): Defects were left untreated; Group G: Defects were covered with autologous bone graft; Group BG: Defects were filled with bioactive glass; Group BG/ASC: Defects were filled with bioactive glass seeded with ASCs. The defect size was significantly greater in Group compared to all other groups. Bone density was significantly lower in Group C compared to Group G and Group BG/ASC. Bone regeneration score of Group C was significantly lower than other groups. Group BG/ASC demonstrated lamellar bone and havers canal formation. The results of this study demonstrated that bioactive glass implanted with ASC is a biocompatible construct stimulating radiologically and histologically evident bone regeneration similar to autologous bone grafting. (C) 2016 Wiley Periodicals, Inc.
dc.identifier.doi10.1002/jbm.b.33634
dc.identifier.eissn1552-4981
dc.identifier.issn1552-4973
dc.identifier.pubmed26888652
dc.identifier.urihttps://hdl.handle.net/11424/234339
dc.identifier.wosWOS:000405311700007
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbioactive glass
dc.subjectadipose derived stem cell
dc.subjectbone regeneration
dc.subjectcritical size defect
dc.subjectORBITAL FLOOR FRACTURES
dc.subjectCALVARIAL DEFECTS
dc.subjectBONE DEFECTS
dc.subjectAUTOGENOUS BONE
dc.subjectSTROMAL CELLS
dc.subjectIN-VIVO
dc.subjectRECONSTRUCTION
dc.subjectTISSUE
dc.subjectAUGMENTATION
dc.subjectREGENERATION
dc.titleRepair of critical size defects using bioactive glass seeded with adipose-derived mesenchymal stem cells
dc.typearticle
dspace.entity.typePublication
local.avesis.id46e23e79-fa4f-4c5a-8010-f7a8d76e7dad
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
local.journal.quartileQ1
oaire.citation.endPage1008
oaire.citation.issue5
oaire.citation.startPage1002
oaire.citation.titleJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
oaire.citation.volume105
relation.isAuthorOfPublication81633a07-e5fb-4760-b3ef-bf0878d87827
relation.isAuthorOfPublication.latestForDiscovery81633a07-e5fb-4760-b3ef-bf0878d87827

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