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Fabrication Strategies for Bioceramic Scaffolds in Bone Tissue Engineering with Generative Design Applications

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dc.contributor.authorKURT, MUSTAFA
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsCinici B., Yaba S., KURT M., Yalcin H. C., Duta L., GÜNDÜZ O.
dc.date.accessioned2024-08-05T11:19:47Z
dc.date.available2024-08-05T11:19:47Z
dc.date.issued2024-07-01
dc.description.abstractThe aim of this study is to provide an overview of the current state-of-the-art in the fabrication of bioceramic scaffolds for bone tissue engineering, with an emphasis on the use of three-dimensional (3D) technologies coupled with generative design principles. The field of modern medicine has witnessed remarkable advancements and continuous innovation in recent decades, driven by a relentless desire to improve patient outcomes and quality of life. Central to this progress is the field of tissue engineering, which holds immense promise for regenerative medicine applications. Scaffolds are integral to tissue engineering and serve as 3D frameworks that support cell attachment, proliferation, and differentiation. A wide array of materials has been explored for the fabrication of scaffolds, including bioceramics (i.e., hydroxyapatite, beta-tricalcium phosphate, bioglasses) and bioceramic–polymer composites, each offering unique properties and functionalities tailored to specific applications. Several fabrication methods, such as thermal-induced phase separation, electrospinning, freeze-drying, gas foaming, particle leaching/solvent casting, fused deposition modeling, 3D printing, stereolithography and selective laser sintering, will be introduced and thoroughly analyzed and discussed from the point of view of their unique characteristics, which have proven invaluable for obtaining bioceramic scaffolds. Moreover, by highlighting the important role of generative design in scaffold optimization, this review seeks to pave the way for the development of innovative strategies and personalized solutions to address significant gaps in the current literature, mainly related to complex bone defects in bone tissue engineering.
dc.identifier.citationCinici B., Yaba S., KURT M., Yalcin H. C., Duta L., GÜNDÜZ O., "Fabrication Strategies for Bioceramic Scaffolds in Bone Tissue Engineering with Generative Design Applications", Biomimetics, cilt.9, sa.7, 2024
dc.identifier.doi10.3390/biomimetics9070409
dc.identifier.issn2313-7673
dc.identifier.issue7
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85199601905&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/297385
dc.identifier.volume9
dc.language.isoeng
dc.relation.ispartofBiomimetics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiyomedikal Mühendisliği
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectBiomedical Engineering
dc.subjectLife Sciences
dc.subjectBiotechnology
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMühendislik
dc.subjectMalzeme Bilimi
dc.subjectMikrobiyoloji
dc.subjectMALZEME BİLİMİ, BİYOMATERYAL
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectMÜHENDİSLİK, BİYOMEDİKAL
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectLife Sciences (LIFE)
dc.subjectENGINEERING
dc.subjectMATERIALS SCIENCE
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectMICROBIOLOGY
dc.subjectMATERIALS SCIENCE, BIOMATERIALS
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectBIOTECHNOLOGY & APPLIED MICROBIOLOGY
dc.subjectENGINEERING, BIOMEDICAL
dc.subjectBiyomühendislik
dc.subjectFizik Bilimleri
dc.subjectBiyomalzemeler
dc.subjectBiyokimya
dc.subjectBiyomedikal mühendisliği
dc.subjectMoleküler Tıp
dc.subjectBioengineering
dc.subjectPhysical Sciences
dc.subjectBiomaterials
dc.subjectBiochemistry
dc.subjectMolecular Medicine
dc.subject3D scaffold
dc.subjectbioceramics
dc.subjectbone tissue engineering
dc.subjectcomposites
dc.subjectgenerative design
dc.titleFabrication Strategies for Bioceramic Scaffolds in Bone Tissue Engineering with Generative Design Applications
dc.typearticle
dspace.entity.typePublication
local.avesis.id0a9cd49b-dfd7-4666-a163-4c6d33ec32a5
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationd083c4d9-2537-4f25-bb25-d3d3b738c005
relation.isAuthorOfPublication6f8fbd59-80b1-43bd-bfba-db1b1649c112
relation.isAuthorOfPublication.latestForDiscoveryd083c4d9-2537-4f25-bb25-d3d3b738c005

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