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Untargeted metabolomic profiling of three Crataegus species (hawthorn) and their in vitro biological activities

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dc.contributor.authorŞENKARDEŞ, İSMAİL
dc.contributor.authorsRocchetti, Gabriele; Senizza, Biancamaria; Zengin, Gokhan; Mahomodally, Mohamad Fawzi; Senkardes, Ismail; Lobine, Devina; Lucini, Luigi
dc.date.accessioned2022-03-12T22:54:46Z
dc.date.available2022-03-12T22:54:46Z
dc.date.issued2020
dc.description.abstractBACKGROUND In this investigation, the chemical and biological profiles of three Turkish Crataegus species (Crataegus orientalis, Crataegus szovitsii and Crataegus tanacetifolia) were studied in order to provide the first comprehensive characterization and their health-promoting potential. In this respect, polyphenolic profiles were evaluated using ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. The in vitro antioxidant activities of the Crataegus samples were evaluated by using free-radical scavenging, phosphomolybdenum, ferrous-ion chelating, and reducing power assays. The inhibitory activities against alpha-glucosidase, amylase, cholinesterases (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)), and tyrosinase were also established. RESULTS The untargeted metabolomic approach highlighted the effect of both extraction types and species on the phenolic profiles of different Crateagus tissues (i.e. leaves and twigs). The methanolic extracts showed the maximum radical scavenging and reducing activity in all test systems, whereas for ferrous-ion chelating assays the decocted and infused extracts showed the highest activity. Only the methanolic extracts were effective against AChE and BChE. The extract tested showed remarkable inhibitory effects against tyrosinase and alpha-glucosidase, whereas all the extracts exhibited modest inhibition against alpha-amylase. Overall, the twig extracts of the three species studied showed superior antioxidant and enzyme inhibitory activities. CONCLUSION On the basis of these results, the three Crataegus species can be classified as potent bioresources for high-value phytochemicals, which warrant further investigations for developing novel nutraceuticals. (c) 2019 Society of Chemical Industry
dc.identifier.doi10.1002/jsfa.10216
dc.identifier.eissn1097-0010
dc.identifier.issn0022-5142
dc.identifier.pubmed31849067
dc.identifier.urihttps://hdl.handle.net/11424/236516
dc.identifier.wosWOS:000508953400001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjecthawthorn
dc.subjectantioxidant
dc.subjectenzyme inhibitor
dc.subjectphytochemicals
dc.subjectPHYTOCHEMICAL CHARACTERIZATION
dc.subjectPOLYMERIC PROCYANIDINS
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectLEAVES
dc.subjectEXTRACT
dc.subjectFRUIT
dc.subjectINHIBITION
dc.subjectSPP.
dc.subjectGLYCOSIDES
dc.subjectFLOWERS
dc.titleUntargeted metabolomic profiling of three Crataegus species (hawthorn) and their in vitro biological activities
dc.typearticle
dspace.entity.typePublication
local.avesis.id3d794aff-2d79-45b8-bf0a-7453050e38d6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
local.journal.quartileQ1
oaire.citation.endPage2006
oaire.citation.issue5
oaire.citation.startPage1998
oaire.citation.titleJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
oaire.citation.volume100
relation.isAuthorOfPublication3e59035c-d7b1-4887-b78c-2a9bc207de05
relation.isAuthorOfPublication.latestForDiscovery3e59035c-d7b1-4887-b78c-2a9bc207de05

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