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The effect of azithromycin on reactive oxygen species in rosacea

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dc.contributor.authorHAKLAR, GONCAGÜL
dc.contributor.authorsBakar, O.; Demircay, Z.; Yuksel, M.; Haklar, G.; Sanisoglu, Y.
dc.date.accessioned2022-03-12T17:33:11Z
dc.date.available2022-03-12T17:33:11Z
dc.date.issued2007
dc.description.abstractBackground: Recent evidence suggests that inflammation in rosacea is associated with generation of reactive oxygen species (ROS) that are released by inflammatory cells. The efficacy of current therapeutic agents for rosacea such as tetracyclines and metronidazole has also been attributed to their antioxidant properties. Recently, a macrolide antibiotic, azithromycin, has been found to be an effective alternative in the treatment of rosacea. Aim: We planned a study to evaluate the antioxidant effects of azithromycin on ROS in rosacea. We compared basal ROS concentrations measured in the facial skin of patients with rosacea with the post-treatment levels and with those of healthy controls. Methods: Facial skin biopsies of 17 papulopustular patients with rosacea and 25 healthy controls were taken. Rosacea patients were assigned to receive oral azithromycin 500 mg on three consecutive days each week for 4 weeks. The total number of inflammatory lesions (the sum of papules and pustules) on the face of each patient with rosacea was counted at each visit. The luminol- and lucigenin-enhanced chemiluminescence (CL) levels of patients with rosacea were measured before and after 4 weeks of treatment and compared with those of healthy controls. Results: Rosacea patients had higher ROS levels than healthy controls (P < 0.001). A statistically significant decrease of both luminol- and lucigenin-enhanced CL levels were observed in patients with rosacea after treatment with azithromycin (t = 4.602, P < 0.001; vs. t = 4.634, P < 0.001, respectively). Conclusion: Rosacea patients have higher ROS levels than healthy controls. The results of our study support the antioxidant properties of azithromycin in rosacea.
dc.identifier.doi10.1111/j.1365-2230.2006.02322.x
dc.identifier.eissn1365-2230
dc.identifier.issn0307-6938
dc.identifier.pubmed17244346
dc.identifier.urihttps://hdl.handle.net/11424/228791
dc.identifier.wosWOS:000244003200015
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofCLINICAL AND EXPERIMENTAL DERMATOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPOSSIBLE MECHANISM
dc.subjectHUMAN NEUTROPHILS
dc.subjectAZELAIC ACID
dc.subjectMETRONIDAZOLE
dc.subjectGENERATION
dc.titleThe effect of azithromycin on reactive oxygen species in rosacea
dc.typearticle
dspace.entity.typePublication
local.avesis.id60fe86d0-aa14-4dc0-ad01-f309bfb58edd
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages4
oaire.citation.endPage200
oaire.citation.issue2
oaire.citation.startPage197
oaire.citation.titleCLINICAL AND EXPERIMENTAL DERMATOLOGY
oaire.citation.volume32
relation.isAuthorOfPublication27f9fd8a-7791-4b61-a4c5-518c52435a15
relation.isAuthorOfPublication.latestForDiscovery27f9fd8a-7791-4b61-a4c5-518c52435a15

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