Publication:
Health-Related Quality of Life During Postoperative Chemoradiotherapy with Oral Uracil-Tegafur and Leucovorin in Rectal Cancer Patients

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dc.contributor.authorATASOY, BESTE MELEK
dc.contributor.authorsOzgen, Zerrin; Ozden, Sevgi; Dane, Faysal; Atasoy, Beste M.; Akgunt, Zuleyha; Yumuk, P. Fulden; Mayadagli, Alpaslan; Turhal, N. Serdar; Abacioglu, Ufuk
dc.date.accessioned2022-03-12T18:11:12Z
dc.date.available2022-03-12T18:11:12Z
dc.date.issued2013
dc.description.abstractBackground/Aims: The objective of this study was to report on the quality of life of locally advanced rectal cancer patients that were treated with uracil-tegafur (UFT)/leucovorin (LV)-based concurrent chemoradiotherapy. Methodology: Twenty-five patients were enrolled into this prospective study. Radiotherapy (50.4Gy) was given with concurrent UFT (300mg/m(2)/day) and LV (30mg/day). Turkish versions of EORTC-QLQC30 and EORTC QLQCR38 were applied at the beginning (HROoL-1) and at the end (HRQoL-2) of chemoradiotherapy. Paired samples t-test was used to compare the difference of means for each scale between HRQoL1 and HRQoL2 and p values <0.05 were considered statistically significant. Results: Study compliance was 80.6%. From baseline to the end of chemoradiotherapy, the mean scores of dyspnea (p=0.006) diarrhea (p=0.005) and micturition (p=0.005) increased significantly. Chemotherapy side effects also increased at the end of therapy (p=0.07). Seventy-six percent (76%) of male patients replied to questions related to sexual problems and functions, whereas no female patients replied. Conclusions: Although, diarrhea and micturition are the major problems, quality of life scores indicate that concurrent oral fluoropyrimidine-based chemoradiotherapy is a feasible treatment.
dc.identifier.doi10.5754/hge12792
dc.identifier.issn0172-6390
dc.identifier.pubmed23159353
dc.identifier.urihttps://hdl.handle.net/11424/231437
dc.identifier.wosWOS:000320740500028
dc.language.isoeng
dc.publisherH G E UPDATE MEDICAL PUBLISHING S A
dc.relation.ispartofHEPATO-GASTROENTEROLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChemoradiotherapy
dc.subjectConcomitant
dc.subjectHealth-related quality of life
dc.subjectRectal cancer
dc.subjectUFT
dc.subjectADJUVANT THERAPY
dc.subjectPHASE-III
dc.subjectRADIOTHERAPY
dc.subjectFLUOROURACIL
dc.subjectMULTICENTER
dc.subjectQLQ-C30
dc.subjectUFT
dc.titleHealth-Related Quality of Life During Postoperative Chemoradiotherapy with Oral Uracil-Tegafur and Leucovorin in Rectal Cancer Patients
dc.typearticle
dspace.entity.typePublication
local.avesis.id81f2099d-9a55-4da2-8f8f-10bfd709ec05
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage537
oaire.citation.issue123
oaire.citation.startPage533
oaire.citation.titleHEPATO-GASTROENTEROLOGY
oaire.citation.volume60
relation.isAuthorOfPublication22ce1b48-93da-4e88-a61e-be24b5e6122a
relation.isAuthorOfPublication.latestForDiscovery22ce1b48-93da-4e88-a61e-be24b5e6122a

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