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Early life risk factors of motor, cognitive and language development: a pooled analysis of studies from low/middle-income countries

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dc.contributor.authorSAVE, DİLŞAD
dc.contributor.authorsSania, Ayesha; Sudfeld, Christopher R.; Danaei, Goodarz; Fink, Gunther; McCoy, Dana C.; Zhu, Zhaozhong; Fawzi, Mary C. Smith; Akman, Mehmet; Arifeen, Shams E.; Barros, Aluisio J. D.; Bellinger, David; Black, Maureen M.; Bogale, Alemtsehay; Braun, Joseph M.; van den Broek, Nynke; Carrara, Verena; Duazo, Paulita; Duggan, Christopher; Fernald, Lia C. H.; Gladstone, Melissa; Hamadani, Jena; Handal, Alexis J.; Harlow, Sioban; Hidrobo, Melissa; Kuzawa, Chris; Kvestad, Ingrid; Locks, Lindsey; Manji, Karim; Masanja, Honorati; Matijasevich, Alicia; McDonald, Christine; McGready, Rose; Rizvi, Arjumand; Santos, Darci; Santos, Leticia; Save, Dilsad; Shapiro, Roger; Stoecker, Barbara; Strand, Tor A.; Taneja, Sunita; Tellez-Rojo, Martha-Maria; Tofail, Fahmida; Yousafzai, Aisha K.; Ezzati, Majid; Fawzi, Wafaie
dc.date.accessioned2022-03-14T10:21:18Z
dc.date.available2022-03-14T10:21:18Z
dc.date.issued2019-10
dc.description.abstractObjective To determine the magnitude of relationships of early life factors with child development in low/middle-income countries (LMICs). Design Meta-analyses of standardised mean differences (SMDs) estimated from published and unpublished data. Data sources We searched Medline, bibliographies of key articles and reviews, and grey literature to identify studies from LMICs that collected data on early life exposures and child development. The most recent search was done on 4 November 2014. We then invited the first authors of the publications and investigators of unpublished studies to participate in the study. Eligibility criteria for selecting studies Studies that assessed at least one domain of child development in at least 100 children under 7 years of age and collected at least one early life factor of interest were included in the study. Analyses Linear regression models were used to assess SMDs in child development by parental and child factors within each study. We then produced pooled estimates across studies using random effects meta-analyses. Results We retrieved data from 21 studies including 20 882 children across 13 LMICs, to assess the associations of exposure to 14 major risk factors with child development. Children of mothers with secondary schooling had 0.14 SD (95% CI 0.05 to 0.25) higher cognitive scores compared with children whose mothers had primary education. Preterm birth was associated with 0.14 SD (-0.24 to -0.05) and 0.23 SD (-0.42 to -0.03) reductions in cognitive and motor scores, respectively. Maternal short stature, anaemia in infancy and lack of access to clean water and sanitation had significant negative associations with cognitive and motor development with effects ranging from -0.18 to -0.10 SDs. Conclusions Differential parental, environmental and nutritional factors contribute to disparities in child development across LMICs. Targeting these factors from prepregnancy through childhood may improve health and development of children.
dc.identifier.doi10.1136/bmjopen-2018-026449
dc.identifier.issn2044-6055
dc.identifier.pubmed31585969
dc.identifier.urihttps://hdl.handle.net/11424/244381
dc.identifier.wosWOS:000512882200018
dc.language.isoeng
dc.publisherBMJ PUBLISHING GROUP
dc.relation.ispartofBMJ OPEN
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLOW-BIRTH-WEIGHT
dc.subjectGESTATIONAL-AGE CHILDREN
dc.subjectMENTAL-DEVELOPMENT
dc.subjectPRETERM CHILDREN
dc.subjectIRON-DEFICIENCY
dc.subjectDOUBLE-BLIND
dc.subjectNUTRITION INTERVENTIONS
dc.subjectZINC SUPPLEMENTATION
dc.subjectMATERNAL EDUCATION
dc.subjectINFANTS
dc.titleEarly life risk factors of motor, cognitive and language development: a pooled analysis of studies from low/middle-income countries
dc.typearticle
dspace.entity.typePublication
local.avesis.id941a7ffc-9f6a-47c8-8ebb-ce80011ce347
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumbere026449
local.journal.numberofpages13
local.journal.quartileQ2
oaire.citation.issue10
oaire.citation.titleBMJ OPEN
oaire.citation.volume9
relation.isAuthorOfPublication3ec94b0b-045a-450e-9358-c2053533dcce
relation.isAuthorOfPublication.latestForDiscovery3ec94b0b-045a-450e-9358-c2053533dcce

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