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Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorERTAŞ, BÜŞRA
dc.contributor.authorsYALMAN K., ŞEN A., ÇEVİK Ö., KADIOĞLU YAMAN S. B. , ERTAŞ B., Yıldız S., ŞENER G.
dc.date.accessioned2022-11-18T17:58:01Z
dc.date.available2022-11-18T17:58:01Z
dc.date.issued2022-01-01
dc.description.abstractThis study investigated the possible protective and therapeutic effects of Myrtus communis subsp. communis ethanol extract (MC) in aluminum chloride (AlCl3) and D-galactose (D-Gal) induced Alzheimer's disease in rats. MC was orally given to rats as a protective treatment for 90 days and, in other two groups starting from the 60th day MC (100-200 mg/kg) was administered, concomitantly with AlCl3 and D-Gal. Learning and memory functions were evaluated by the behavioral tests. Biological activities of MC treatment were examined in hippocampal tissues by ELISA tests. D-Gal and AlCl3-treated rats showed increased amyloid beta (Aβ) and 8-hydroxy-2-deoxyguanosine (8- OHdG) levels, acetylcholinesterase activity and decreased neprilysin, Na+-K+ATPase and SOD levels in parallel with a decrease in Novel Object Recognition Test, Morris Water Maze and Passive Avoidance Test scores. On the other hand, MC administration reversed the behavioral impairments and improved learning and memory. Moreover, MC treatment decreased Aβ and 8-OHdG levels and acetylcholinesterase activity and increased neprilysin levels, Na+-K+ATPase and SOD levels. Our results suggest that MC has beneficial effects on cognitive and neuronal functions through its anticholinesterase and antioxidant properties.
dc.identifier.citationYALMAN K., ŞEN A., ÇEVİK Ö., KADIOĞLU YAMAN S. B. , ERTAŞ B., Yıldız S., ŞENER G., "Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats", JOURNAL OF RESEARCH IN PHARMACY, cilt.26, sa.5, 2022
dc.identifier.doi10.29228/jrp.242
dc.identifier.issn2630-6344
dc.identifier.issue5
dc.identifier.urihttps://www.jrespharm.com/abstract.php?lang=en&id=1112
dc.identifier.urihttps://hdl.handle.net/11424/283232
dc.identifier.volume26
dc.language.isoeng
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMyrtle
dc.subjectantioxidant activity
dc.subjectanticholinesterase activity
dc.subjectcognitive impairment
dc.titleInvestigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idd272beed-59c6-4792-a538-7ff2604b2832
local.indexed.atSCOPUS
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication864e7cb0-b39f-48bb-a546-ee65ffc807b2
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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