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European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations

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dc.contributor.authorDUMAN, DENİZ
dc.contributor.authorsLohr, J-Matthias; Beuers, Ulrich; Vujasinovic, Miroslav; Alvaro, Domenico; Frokjaer, Jens Brondum; Buttgereit, Frank; Capurso, Gabriele; Culver, Emma L.; De-Madaria, Enrique; Della-Torre, Emanuel; Detlefsen, Sonke; Dominguez-Munoz, Enrique; Czubkowski, Piotr; Ewald, Nils; Frulloni, Luca; Gubergrits, Natalya; Duman, Deniz Guney; Hackert, Thilo; Iglesias-Garcia, Julio; Kartalis, Nikolaos; Laghi, Andrea; Lammert, Frank; Lindgren, Fredrik; Okhlobystin, Alexey; Oracz, Grzegorz; Parniczky, Andrea; Mucelli, Raffaella Maria Pozzi; Rebours, Vinciane; Rosendahl, Jonas; Schleinitz, Nicolas; Schneider, Alexander; van Bommel, Eric F. H.; Verbeke, Caroline Sophie; Vullierme, Marie Pierre; Witt, Heiko; Besselink, Marc G.; Bruno, Marco J.; Czako, Laszlo; del Chiaro, Marco; Filippova, Oleksandra; Fukuda, Akihisa; Gaujoux, Sebastien; Hart, Phil A.; Hegyi, Peter; Jonas, Eduard; Kahraman, Alisan; Kleger, Alexander; Kuryata, Olexander; Laukkarinen, Johanna; Lerch, Markus M.; Marchegiani, Giovanni; Marschal, Hanns-Ulrich; Matos, Celso; Molad, Yair; Oguz, Dilek; Pukitis, Aldis; Satoi, Sohei; Stone, John H.; Verheij, Joanne; de Vries, Niek
dc.date.accessioned2022-03-14T09:28:49Z
dc.date.available2022-03-14T09:28:49Z
dc.date.issued2020-07
dc.description.abstractThe overall objective of these guidelines is to provide evidence-based recommendations for the diagnosis and management of immunoglobulin G4 (IgG4)-related digestive disease in adults and children. IgG4-related digestive disease can be diagnosed only with a comprehensive work-up that includes histology, organ morphology at imaging, serology, search for other organ involvement, and response to glucocorticoid treatment. Indications for treatment are symptomatic patients with obstructive jaundice, abdominal pain, posterior pancreatic pain, and involvement of extra-pancreatic digestive organs, including IgG4-related cholangitis. Treatment with glucocorticoids should be weight-based and initiated at a dose of 0.6-0.8 mg/kg body weight/day orally (typical starting dose 30-40 mg/day prednisone equivalent) for 1 month to induce remission and then be tapered within two additional months. Response to initial treatment should be assessed at week 2-4 with clinical, biochemical and morphological markers. Maintenance treatment with glucocorticoids should be considered in multi-organ disease or history of relapse. If there is no change in disease activity and burden within 3 months, the diagnosis should be reconsidered. If the disease relapsed during the 3 months of treatment, immunosuppressive drugs should be added.
dc.identifier.doi10.1177/2050640620934911
dc.identifier.eissn2050-6414
dc.identifier.issn2050-6406
dc.identifier.pubmed32552502
dc.identifier.urihttps://hdl.handle.net/11424/243175
dc.identifier.wosWOS:000542363500001
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS INC
dc.relation.ispartofUNITED EUROPEAN GASTROENTEROLOGY JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIgG4-related
dc.subjectdigestive
dc.subjectdisease
dc.subjectglucocorticoids
dc.subjectother organ involvement
dc.subjectbiomarkers
dc.subjectautoimmune pancreatitis type 1
dc.subjectimmune-related cholangitis
dc.subjectcancer
dc.subjectdiabetes mellitus
dc.subjectIMMUNOGLOBULIN G4-RELATED DISEASE
dc.subjectTYPE-1 AUTOIMMUNE PANCREATITIS
dc.subjectFINE-NEEDLE-ASPIRATION
dc.subjectLONG-TERM OUTCOMES
dc.subjectPRIMARY SCLEROSING CHOLANGITIS
dc.subjectEMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY
dc.subjectCONSENSUS DIAGNOSTIC-CRITERIA
dc.subjectSERUM IGG4 LEVELS
dc.subjectSTEROID-THERAPY
dc.subjectINTERNATIONAL-CONSENSUS
dc.titleEuropean Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations
dc.typearticle
dspace.entity.typePublication
local.avesis.idc7bfb92f-cf44-4c75-879d-ffb7cea7b1cd
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber2050640620934910
local.journal.numberofpages30
local.journal.quartileQ2
oaire.citation.endPage666
oaire.citation.issue6
oaire.citation.startPage637
oaire.citation.titleUNITED EUROPEAN GASTROENTEROLOGY JOURNAL
oaire.citation.volume8
relation.isAuthorOfPublicationfbd7db24-b703-41cb-8619-c66129ba9556
relation.isAuthorOfPublication.latestForDiscoveryfbd7db24-b703-41cb-8619-c66129ba9556

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