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The effects of iron deficiency on infants' developmental test performance

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dc.contributor.authorSAVE, DİLŞAD
dc.contributor.authorsAkman, M; Cebeci, D; Okur, V; Angin, H; Abali, O; Akman, AC
dc.date.accessioned2022-03-12T17:17:38Z
dc.date.available2022-03-12T17:17:38Z
dc.date.issued2004
dc.description.abstractAim: To assess the effects of iron deficiency on developmental test scores in infants. Methods: This prospective, single-blind, controlled clinical intervention study was made on 108 children aged 6-30 mo who applied to our paediatric outpatient clinic. The cases were classified as control (n = 31, haemoglobin greater than or equal to11 g/dl, serum ferritin > 12 mug/l, MCV greater than or equal to70 fl), non-anaemic iron deficiency (NAID, n = 40, haemoglobin greater than or equal to 11 g/dl, serum ferritin less than or equal to 12 mug/l, MCV greater than or equal to70 fl) and iron deficiency anaemia (IDA, n = 37, haemoglobin <11 g/dl, ferritin &LE; 12 &mu;g/l, MCV <70 fl) due to their anaemia status. In each group, MCV, haemoglobin and ferritin levels were measured, and Denver Developmental Screening Test (DDST) and Bayley Scales of Infant Development (BSID-I) were administered before and after a 3-mo follow-up. IDA and about half of the NAID subjects were treated with oral iron for 3 mo. Results: Subjects with iron deficiency showed significantly lower developmental test scores both with BSID-I and DDST-II compared to their iron-sufficient peers (p < 0.05). After 3 mo of iron treatment, lower mental developmental test scores were no longer observed among the IDA and NAID groups whose anaemia and iron deficiency were also corrected. No significant differences were found between control NAID and control IDA groups on DGTT-II results after treatment. The difference in motor and mental developmental scores did not appear to depend on environmental and family factors considered in the analyses. Conclusion: These findings support the conclusions that iron deficiency may cause lower mental I and motor test scores in infants and these adverse effects can be improved by iron therapy.
dc.identifier.doi10.1080/08035250410030946
dc.identifier.issn0803-5253
dc.identifier.pubmed15499963
dc.identifier.urihttps://hdl.handle.net/11424/227880
dc.identifier.wosWOS:000224252100022
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS AS
dc.relation.ispartofACTA PAEDIATRICA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanaemia
dc.subjectinfant
dc.subjectiron deficiency
dc.subjectmental development
dc.subjectmotor development
dc.subjectPSYCHOMOTOR DEVELOPMENT
dc.subjectANEMIA
dc.subjectTHERAPY
dc.subjectBEHAVIOR
dc.subjectSCORES
dc.titleThe effects of iron deficiency on infants' developmental test performance
dc.typearticle
dspace.entity.typePublication
local.avesis.id6ce87662-2f79-474e-b928-ed51b2cb5b02
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage1396
oaire.citation.issue10
oaire.citation.startPage1391
oaire.citation.titleACTA PAEDIATRICA
oaire.citation.volume93
relation.isAuthorOfPublication3ec94b0b-045a-450e-9358-c2053533dcce
relation.isAuthorOfPublication.latestForDiscovery3ec94b0b-045a-450e-9358-c2053533dcce

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