Publication:
Propolis-Based Nanofiber Patches to Repair Corneal Microbial Keratitis

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsUlag, Songul; Ilhan, Elif; Demirhan, Ramazan; Sahin, Ali; Yilmaz, Betul Karademir; Aksu, Burak; Sengor, Mustafa; Ficai, Denisa; Titu, Aurel Mihail; Ficai, Anton; Gunduz, Oguzhan
dc.date.accessioned2022-03-14T09:56:31Z
dc.date.available2022-03-14T09:56:31Z
dc.date.issued2021-04-28
dc.description.abstractIn this research, polyvinyl-alcohol (PVA)/gelatin (GEL)/propolis (Ps) biocompatible nanofiber patches were fabricated via electrospinning technique. The controlled release of Propolis, surface wettability behaviors, antimicrobial activities against the S. aureus and P. aeruginosa, and biocompatibility properties with the mesenchymal stem cells (MSCs) were investigated in detail. By adding 0.5, 1, and 3 wt.% GEL into the 13 wt.% PVA, the morphological and mechanical results suggested that 13 wt.% PVA/0.5 wt.% GEL patch can be an ideal matrix for 3 and 5 wt.% propolis addition. Morphological results revealed that the diameters of the electrospun nanofiber patches were increased with GEL (from 290 nm to 400 nm) and Ps addition and crosslinking process cause the formation of thicker nanofibers. The tensile strength and elongation at break enhancement were also determined for 13 wt.% PVA/0.5 wt.% GEL/3 wt.% Ps patch. Propolis was released quickly in the first hour and arrived at a plateau. Cell culture and contact angle results confirmed that the 3 wt.% addition of propolis reinforced mesenchymal stem cell proliferation and wettability properties of the patches. The antimicrobial activity demonstrated that propolis loaded patches had antibacterial activity against the S. aureus, but for P. aeruginosa, more studies should be performed.
dc.identifier.doi10.3390/molecules26092577
dc.identifier.eissn1420-3049
dc.identifier.pubmed33925130
dc.identifier.urihttps://hdl.handle.net/11424/243724
dc.identifier.wosWOS:000650655800001
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofMOLECULES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcorneal patch
dc.subjectelectrospinning
dc.subjectmicrobial keratitis
dc.subjectnanofibers
dc.subjectpropolis
dc.subjectP
dc.subjectaeruginosa
dc.subjectS
dc.subjectaureus
dc.subjectCHEMICAL-COMPOSITION
dc.subjectELECTROSPUN
dc.subjectSCAFFOLD
dc.subjectGELATIN
dc.subjectFABRICATION
dc.subjectCOMPOSITE
dc.subjectBLINDNESS
dc.subjectMEMBRANE
dc.subjectPROPERTY
dc.subjectHYDROGEL
dc.titlePropolis-Based Nanofiber Patches to Repair Corneal Microbial Keratitis
dc.typearticle
dspace.entity.typePublication
local.avesis.id7f7f212e-5bed-46bc-9126-dd7c172cea59
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber2577
local.journal.numberofpages16
oaire.citation.issue9
oaire.citation.titleMOLECULES
oaire.citation.volume26
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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