Publication:
Antimicrobial, Antioxidant and Antiproliferative Activities of Novel Quinolones

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dc.contributor.authorBİNGÖL ÖZAKPINAR, ÖZLEM
dc.contributor.authorsCeylan, Sule; Cebeci, Yildiz Uygun; Demirbas, Neslihan; Batur, Ozge Ozsen; Ozakpinar, Ozlem Bingol
dc.date.accessioned2022-03-12T22:44:44Z
dc.date.available2022-03-12T22:44:44Z
dc.date.issued2020
dc.description.abstractThe compound (2) formed by esterification of dimethyl morpholine (1) was converted to acetohydrazide (3). Subsequently Schiff bases (4 a-d) and carboxy(thio)amide derivatives (5 a-e) were synthesized. Then 1,2,4-triazole (6 a-e), thia(oxa)zolidine (7 c,e) and thia(oxa)zol (8 c,e) derivatives were obtained by ring closure from carboxy(thio)amides. Mannich bases, which are containing quinolone were synthesized from 1,2,4-triazoles. The structures of newly synthesized compounds were illuminated by spectroscopic methods. Their antimicrobial (MIC method), antioxidant (DPPH, FRAP, and CUPRAC methods), and anticancer activities (MTT method) were examined. Results showed that most of the compounds exhibited good antimicrobial (<0.03-31.25 mu g/mL with MIC values) and antioxidant activities (IC50=0.001-0.004 with DPPH values). Also, some of the compounds have been found to have antiproliferative effects on the prostate (PC-3), liver (Hep3B), and breast (MCF-7) human cancer cells, and also these compounds did not have a cytotoxic effect on a normal cell.
dc.identifier.doi10.1002/slct.202002779
dc.identifier.issn2365-6549
dc.identifier.urihttps://hdl.handle.net/11424/236460
dc.identifier.wosWOS:000573626900027
dc.language.isoeng
dc.publisherWILEY-V C H VERLAG GMBH
dc.relation.ispartofCHEMISTRYSELECT
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject1
dc.subject2
dc.subject4-triazole
dc.subjectquinolone
dc.subjectantioxidant
dc.subjectantimicrobial
dc.subjectanticancer activity
dc.subjectMANNICH-BASES
dc.subjectIN-VITRO
dc.subjectBIOLOGICAL EVALUATION
dc.subjectSCHIFF-BASES
dc.subjectDERIVATIVES
dc.subjectANTIFUNGAL
dc.subjectANTICANCER
dc.subjectDRUG
dc.subjectTRIAZOLOTHIADIAZOLES
dc.subject1,2,4-TRIAZOLES
dc.titleAntimicrobial, Antioxidant and Antiproliferative Activities of Novel Quinolones
dc.typearticle
dspace.entity.typePublication
local.avesis.ide6860613-1e2a-4a8a-80f7-db031d7953c9
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages7
local.journal.quartileQ3
oaire.citation.endPage11346
oaire.citation.issue36
oaire.citation.startPage11340
oaire.citation.titleCHEMISTRYSELECT
oaire.citation.volume5
relation.isAuthorOfPublication44b61e5d-4045-4d63-926e-2f01c3ee5642
relation.isAuthorOfPublication.latestForDiscovery44b61e5d-4045-4d63-926e-2f01c3ee5642

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