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New candidate chromosomal regions for chordoma development

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dc.contributor.authorGÜNEY, AHMET İLTER
dc.contributor.authorsBayrakli, Fatih; Guney, Ilter; Kilic, Turker; Ozek, Memet; Pamir, Mustafa Necmettin
dc.date.accessioned2022-03-12T17:32:55Z
dc.date.available2022-03-12T17:32:55Z
dc.date.issued2007
dc.description.abstractBackground: Chordomas are rare, slow growing, infiltrative tumors thought to arise from vestigial or ectopic notochord. Chordoma can occur along the axial skeleton, predominantly in the sphenooccipital, vertebral, and sacrococcygeal regions. Although most chordomas are sporadic, familial cases have also been reported. The most common molecular cytogenetic abnormalities in these tumors are monosomy of chromosome I and gain of chromosome 7. In addition, a variety of other chromosomal changes, which are associated with losses and gains of different chromosomes, have also been described in chordomas, such as 1q, 2p, 3p, 5q, 9p, 10, l2q, 13q, 17, and 20q. Methods: In this study, using molecular cytogenetics (iFISH), we have studied 1p36, 1q25, 3p13p14, 7q33, 17p13.1 (p53 gene locus), 2p13 (TGF-alpha locus), 6p12 (VEGF locus), and 4q26-q27 (bFGF/FGF2 locus) loci in chordoma tissues from seven patients with 7 primary tumors and 11 recurrences. Results: We found that chromosomes 1p36, 1q25, 2p13, and 7q33 are affected in primary chordomas, and these aberrations persist in recurrences. However, the chromosome 6p12 aberration was seen only in primary chordomas, but not in recurrences, indicating that this locus may be associated with chordoma genesis. Conclusions: Our descriptive data from interphase FISH analyses suggest that future studies should incorporate a larger number of patients and should focus on identifying the candidate genes in chordoma pathogenesis. Such studies may use a whole-genomic approach, in addition to the regions identified in this study and others. (C) 2007 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.surneu.2006.11.046
dc.identifier.issn0090-3019
dc.identifier.pubmed17714767
dc.identifier.urihttps://hdl.handle.net/11424/228727
dc.identifier.wosWOS:000250158400014
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofSURGICAL NEUROLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectchordoma
dc.subjectFISH
dc.subjectchoromosomal abberations
dc.subjectSKULL-BASE CHORDOMAS
dc.subjectFAMILIAL CHORDOMA
dc.subjectCYTOGENETIC ANALYSIS
dc.subjectTUMOR
dc.subjectDNA
dc.subjectEXPRESSION
dc.subjectABNORMALITIES
dc.subjectHYBRIDIZATION
dc.subjectEXPERIENCE
dc.subjectPROTEINS
dc.titleNew candidate chromosomal regions for chordoma development
dc.typearticle
dspace.entity.typePublication
local.avesis.id770e0b71-37bc-4a3f-981a-97d0bc3a985b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages6
oaire.citation.endPage430
oaire.citation.issue4
oaire.citation.startPage425
oaire.citation.titleSURGICAL NEUROLOGY
oaire.citation.volume68
relation.isAuthorOfPublicationd474fc8a-ae88-487e-b63b-7f506191fb94
relation.isAuthorOfPublication.latestForDiscoveryd474fc8a-ae88-487e-b63b-7f506191fb94

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