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Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism

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dc.contributor.authorGÜLLÜOĞLU, MAHMUT BAHADIR
dc.contributor.authorsMakay, Ozer; Ozcinar, Beyza; Simsek, Turgay; Arici, Cumhur; Gungor, Bulent; Ozbas, Serdar; Akca, Tamer; Emre, Ali Ugur; Cakmak, Guldeniz Karadeniz; Akcay, Mufide; Unal, Bulent; Girgin, Mustafa; Girgin, Sadullah; Gorgulu, Semih; Sezer, Atakan; Karatas, Adem; Ozemir, Ibrahim Ali; Aksakal, Nihat; Erel, Serap; Ugurlu, M. Umit; Filiz, Ali Ilker; Atalay, Can; Uzunkoy, Ali; Deveci, Ugur; Kotan, Cetin; Icoz, Gokhan; Kurt, Yavuz; Kebudi, Abut; Canturk, N. Zafer; Erbil, Yesim; Pandev, Rumen; Gulluoglu, Bahadir M.
dc.date.accessioned2022-03-14T08:28:23Z
dc.date.available2022-03-14T08:28:23Z
dc.date.issued2017-01-15
dc.description.abstractBackground: Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. Aims: To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and Anatolia regions. Study Design: Retrospective, clinical-based multicentric study of 694 patients with pHPT. Methods: Patients from 23 centers and 8 different geographical regions were included. Data related to baseline demographics, clinical, pathologic and treatment characteristics of 8 regions were collected and included age, gender, residential data, symptoms, history of fracture, existence of brown tumor, serum total Ca and p levels, serum parathormone (PTH) levels, serum 25-OH vitamin D levels, bone mineral density, size of the resected abnormal parathyroid gland(s), histology, as well as the presence of ectopia, presence of dual adenoma, and multiple endocrine neoplasia (MEN)- or familial-related disease. Results: The median age was 54. Asymptomatic patient rate was 25%. The median PTH level was 232 pg/mL and serum total Ca was 11.4 mg/dL. Eighty-seven percent of patients had an adenoma and 90% of these had a single adenoma. Hyperplasia was detected in 79 patients and cancer in 9 patients. The median adenoma size was 16 mm. Significant parameters differing between regions were preoperative symptoms, serum Ca and p levels, and adenoma size. All patients from South-East Anatolia were symptomatic, while the lowest p values were reported from East Anatolia and the largest adenoma size, as well as highest Ca levels, were from Bulgaria. Conclusion: Habitat conditions vary between geographical regions. This affects the clinicopathological features of patients with pHPT.
dc.identifier.doi10.4274/balkanmedj.2015.0865
dc.identifier.eissn2146-3131
dc.identifier.issn2146-3123
dc.identifier.pubmed28251020
dc.identifier.urihttps://hdl.handle.net/11424/241844
dc.identifier.wosWOS:000396361900004
dc.language.isoeng
dc.publisherGALENOS YAYINCILIK
dc.relation.ispartofBALKAN MEDICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHyperparathyroidism
dc.subjectclinocopathological features
dc.subjectregional differences
dc.subjectTurkey
dc.subjectBulgaria
dc.subjectVITAMIN-D STATUS
dc.subjectPARATHYROID ADENOMA WEIGHT
dc.subjectD DEFICIENCY
dc.subjectEPIDEMIOLOGY
dc.subjectPOPULATION
dc.subjectCARCINOMA
dc.subjectIMPACT
dc.titleRegional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism
dc.typearticle
dspace.entity.typePublication
local.avesis.iddae409c3-efe5-41f2-a194-d4aa4f2f8319
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.indexed.atTRDIZIN
local.journal.numberofpages7
local.journal.quartileQ3
oaire.citation.endPage34
oaire.citation.issue1
oaire.citation.startPage28
oaire.citation.titleBALKAN MEDICAL JOURNAL
oaire.citation.volume34
relation.isAuthorOfPublication6d478db0-15a8-4b2b-878f-dc3d1b256022
relation.isAuthorOfPublication.latestForDiscovery6d478db0-15a8-4b2b-878f-dc3d1b256022

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