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New alternative agents in essential tremor therapy: double-blind placebo-controlled study of alprazolam and acetazolamide

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dc.contributor.authorBEKİROĞLU, GÜLNAZ NURAL
dc.contributor.authorsGunal, DI; Afsar, N; Bekiroglu, N; Aktan, S
dc.date.accessioned2022-03-12T16:59:06Z
dc.date.available2022-03-12T16:59:06Z
dc.date.issued2000
dc.description.abstractPropranolol and primidone are widely used, effective agents in essential tremor although they are not tolerated by all patients. In the present study, the effectiveness of alprazolam, a triazole analog of benzodiazapine class, and acetazolamide, a carbonic anhydrase inhibitor, were investigated as symptomatic treatments for essential tremor. We studied 22 patients with essential tremor in a double-blind, cross-over, placebo-controlled design. The patients received in random order alprazolam, acetazolamide, primidone and placebo for four weeks, each separated by a two-week washout period. The study demonstrated that alprazolam was superior to placebo and equipotent to primidone, whereas there was no statistically significant difference between acetazolamide and placebo. The mean effective daily dose of alprazolam was 0.75 mg and there was not any troublesome side effect reported by the patients on alprazolam. Alprazolam can be used as an alternative agent in elderly essential tremor patients who can not tolerate primidone or propranolol.
dc.identifier.doi10.1007/s100720070069
dc.identifier.issn1590-1874
dc.identifier.pubmed11286044
dc.identifier.urihttps://hdl.handle.net/11424/227149
dc.identifier.wosWOS:000167660900009
dc.language.isoeng
dc.publisherSPRINGER-VERLAG
dc.relation.ispartofNEUROLOGICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectessential tremor therapy
dc.subjectalprazolam
dc.subjectacetazolamide
dc.subjectelderly
dc.subjectPRIMIDONE
dc.subjectEFFICACY
dc.subjectTRIAL
dc.titleNew alternative agents in essential tremor therapy: double-blind placebo-controlled study of alprazolam and acetazolamide
dc.typearticle
dspace.entity.typePublication
local.avesis.id40a51818-0a07-4146-9715-1d65d404471d
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages3
oaire.citation.endPage317
oaire.citation.issue5
oaire.citation.startPage315
oaire.citation.titleNEUROLOGICAL SCIENCES
oaire.citation.volume21
relation.isAuthorOfPublication9d562d76-b085-41e7-87b1-114fae3720d0
relation.isAuthorOfPublication.latestForDiscovery9d562d76-b085-41e7-87b1-114fae3720d0

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