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Preparation and characterization of pure natural hydroxyapatite derived from seashells for controlled drug delivery

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dc.contributor.authorOKTAR, FAİK NÜZHET
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorBİLĞİÇ ALKAYA, DİLEK
dc.contributor.authorAYAZ SEYHAN, SERAP
dc.contributor.authorCESUR, SÜMEYYE
dc.contributor.authorsAYAZ SEYHAN S., Alkaya D., Cesur S., OKTAR F. N., GÜNDÜZ O.
dc.date.accessioned2023-06-13T08:35:42Z
dc.date.available2023-06-13T08:35:42Z
dc.date.issued2022-09-01
dc.description.abstractThe marine species are specially used for the fabrication of bioceramic nano-powders with natural methods for their use in controlled drug delivery. However, there are only very limited studies regarding the production and synthesis of hydroxyapatite (HA)-based drug delivery systems from marine structures. In this study, poly (vinyl alcohol) (PVA) containing Rifampicin (RIF)-loaded Orange Spiny Oyster Seashell (Spondylus barbatus) hydroxyapatite (HA) composite is synthesized by an in situ ultrasound-assisted method. All samples were analyzed by X-ray diffraction (XRD), Fourier transforms infrared (FTIR) spectroscopy, and Scanning electron microscope (SEM), respectively. The in vitro drug release tests of the obtained samples were performed in a phosphate-buffered medium (PBS) at 37 degrees C. Drug release was evaluated according to five varying kinetic models. In vitro RIF release from HA/PVA composite in phosphate buffer (pH 7.4) showed prolonged sustained drug release. From the drug release kinetic models, Higuchi and Korsmeyer-Peppas were found to be the best model for the three ratios based on the correlation coefficient. The diffusion component is less than 0.5, which indicates quasi-fickian diffusion. From the kinetic study results, the RIF-loaded marine phase composite has potential use in drug delivery applications as it shows positive sustained drug release behavior.
dc.identifier.citationAYAZ SEYHAN S., Alkaya D., Cesur S., OKTAR F. N., GÜNDÜZ O., "Preparation and characterization of pure natural hydroxyapatite derived from seashells for controlled drug delivery", JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY, cilt.58, sa.4, ss.1231-1240, 2022
dc.identifier.doi10.1007/s41779-022-00739-w
dc.identifier.endpage1240
dc.identifier.issn2510-1560
dc.identifier.issue4
dc.identifier.startpage1231
dc.identifier.urihttps://link.springer.com/article/10.1007/s41779-022-00739-w
dc.identifier.urihttps://hdl.handle.net/11424/290211
dc.identifier.volume58
dc.language.isoeng
dc.relation.ispartofJOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMühendislik ve Teknoloji
dc.subjectEngineering and Technology
dc.subjectMALZEME BİLİMİ, SERAMİK
dc.subjectMalzeme Bilimi
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectMATERIALS SCIENCE, CERAMICS
dc.subjectMATERIALS SCIENCE
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectGenel Malzeme Bilimi
dc.subjectSeramik ve Kompozitler
dc.subjectFizik Bilimleri
dc.subjectGeneral Materials Science
dc.subjectCeramics and Composites
dc.subjectPhysical Sciences
dc.subjectHydroxyapatite
dc.subjectPoly (vinyl alcohol)
dc.subjectRifampicin
dc.subjectPolycomposite
dc.subjectDrug delivery
dc.subjectKinetic model
dc.subjectCERAMIC COMPOSITES
dc.subjectIN-VITRO
dc.subjectRELEASE
dc.subjectSCAFFOLDS
dc.subjectPOWDERS
dc.subjectHydroxyapatite
dc.subjectPoly (vinyl alcohol)
dc.subjectRifampicin
dc.subjectPolycomposite
dc.subjectDrug delivery
dc.subjectKinetic model
dc.titlePreparation and characterization of pure natural hydroxyapatite derived from seashells for controlled drug delivery
dc.typearticle
dspace.entity.typePublication
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local.indexed.atWOS
local.indexed.atSCOPUS
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