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Effects of Probiotic Consumption on Absence Seizures

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsAkkol, Serdar; Dogan, Mehmet Can; Esenkar, Duygu; Dogan, Handan; Karamahmutoglu, Tugba; Onat, Filiz
dc.date.accessioned2022-03-14T08:23:06Z
dc.date.available2022-03-14T08:23:06Z
dc.date.issued2017
dc.description.abstractObjectives: Probiotics are microorganisms of intestinal microflora that are beneficial for human health. Childhood absence epilepsy has 2 validated rat models: Genetic Absence Epilepsy Rats from Strasbourg (GAERS) and Wistar Albino Glaxo from Rijswijk (WAG/Rij). To date, there have been no clinical or experimental studies of the effects of probiotics on absence epilepsy. The present study was an investigation of the effects of probiotics on absence seizures in the GAERS rat model. Methods: GAERS were used to examine the effects of probiotics. Nine male GAERS were assigned to 1 of 2 groups (probiotic or control). The animals had free access to food and water. Commercially available probiotic product was provided in drinking water to probiotic group for 1 month. Surface electrodes were then implanted for electroencephalogram (EEG) recordings. Two aspects of EEG recordings were compared: cumulative duration and cumulative number of absence seizures. Results: Analysis of spike-and-wave discharges between the 2 groups showed no significant difference in either cumulative duration or number (p>0.05). Additionally, it was observed that probiotic group consumed more water than control group (p<0.05). Conclusion: Results indicated that probiotic consumption had no effect on duration or number of spike-and-wave discharges of GAERS after 1-month feeding period. This is the first investigation in the literature addressing interactions between probiotics and absence epilepsy, and further research is needed.
dc.identifier.doi10.14744/epilepsi.2017.59389
dc.identifier.issn1300-7157
dc.identifier.urihttps://hdl.handle.net/11424/241672
dc.identifier.wosWOS:000411366200003
dc.language.isoeng
dc.publisherKARE PUBL
dc.relation.ispartofEPILEPSI
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChildhood absence epilepsy
dc.subjectGenetic Absence Epilepsy Rats from Strasbourg
dc.subjectprobiotics
dc.subjectrat
dc.subjectEPILEPSY
dc.subjectRATS
dc.subjectMECHANISMS
dc.subjectBEHAVIOR
dc.subjectMOUSE
dc.subjectMODEL
dc.subjectGAERS
dc.subjectACID
dc.subjectMICE
dc.titleEffects of Probiotic Consumption on Absence Seizures
dc.typearticle
dspace.entity.typePublication
local.avesis.idf1a38afa-aeed-4001-997a-de197a85510a
local.import.packageSS16
local.indexed.atWOS
local.indexed.atTRDIZIN
local.journal.numberofpages6
oaire.citation.endPage56
oaire.citation.issue2
oaire.citation.startPage51
oaire.citation.titleEPILEPSI
oaire.citation.volume23
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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