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Elevated Plasma Levels of PAI-1 Predict Cardiovascular Events and Cardiovascular Mortality in Prevalent Peritoneal Dialysis Patients

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dc.contributor.authorARIKAN, İZZET HAKKI
dc.contributor.authorsArikan, Hakki; Koc, Mehmet; Tuglular, Serhan; Ozener, Cetin; Akoglu, Emel
dc.date.accessioned2022-03-12T17:37:17Z
dc.date.available2022-03-12T17:37:17Z
dc.date.issued2009
dc.description.abstractBackground. Elevated plasminogen activator inhibitor-1 (PAI-1) levels are associated with increased cardiovascular (CV) risk in the general population. It has been shown that peritoneal dialysis (PD) patients have increased plasma levels of PAI-1. The aim of this study was to investigate whether PAI-1 independently predicted CV outcome in PD patients. Material and Methods. Seventy-two PD patients (53% females, mean age 49.9 +/- 16.1 years) were studied. Twelve patients who underwent kidney transplantation and 14 patients who transferred to hemodialysis during follow-up were excluded from the analysis. The remaining 46 patients (54% female, mean age 54 +/- 16 years, dialytic age 42 +/- 30 months) were followed a mean time of 45.4 +/- 19.4 months (range 8-71 months). Baseline PAI-1, clinical, and laboratory parameters were assessed in all patients. Survival analyses were made with Kaplan-Meier and Cox regression analysis, with all-cause mortality and CV mortality and CV events (CVEs) as clinical end points. Results. During the follow-up, 29 patients died (17 from CV causes), and 28 fatal and non-fatal CVEs were recorded. The patients were divided according to plasma PAI-1 levels (i.e., <= or >41 ng/mL). The significant independent predictors of all-cause of mortality were age (>60 years; p = 0.018), CRP (>5 mg/L; p = 0.015), and serum albumin (<3.5 g/L; p = 0.011). Multivariable Cox regression analysis showed that plasma PAI-1 >41 ng/mL was independently predictive of higher CV mortality (p = 0.021) and CVEs (p = 0.001). The only other independent predictor of CV mortality was only CRP (>5 mg/L; p = 0.008). Conclusions. Plasma levels of PAI-1 >41 ng/mL is a significant predictor of CV mortality and CVEs in PD patients.
dc.identifier.doi10.1080/08860220902963772
dc.identifier.eissn1525-6049
dc.identifier.issn0886-022X
dc.identifier.pubmed19839820
dc.identifier.urihttps://hdl.handle.net/11424/229364
dc.identifier.wosWOS:000269006600003
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofRENAL FAILURE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPAI-1
dc.subjectcardiovascular outcome
dc.subjectperitoneal dialysis
dc.subjectPLASMINOGEN-ACTIVATOR INHIBITOR-1
dc.subjectC-REACTIVE PROTEIN
dc.subjectERYTHROPOIETIN THERAPY
dc.subjectMYOCARDIAL-INFARCTION
dc.subjectHEMODIALYSIS-PATIENTS
dc.subjectINSULIN-RESISTANCE
dc.subjectHEART-DISEASE
dc.subjectRISK-FACTORS
dc.subjectINFLAMMATION
dc.subjectATHEROSCLEROSIS
dc.titleElevated Plasma Levels of PAI-1 Predict Cardiovascular Events and Cardiovascular Mortality in Prevalent Peritoneal Dialysis Patients
dc.typearticle
dspace.entity.typePublication
local.avesis.iddabd46b5-8e81-41f2-acb4-95e6516db202
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
oaire.citation.endPage445
oaire.citation.issue6
oaire.citation.startPage438
oaire.citation.titleRENAL FAILURE
oaire.citation.volume31
relation.isAuthorOfPublication1fe3028b-011e-403a-ac08-1932d177a065
relation.isAuthorOfPublication.latestForDiscovery1fe3028b-011e-403a-ac08-1932d177a065

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