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The prevalence and risk factors of premature thelarche and pubarche in 4-to 8-year-old girls

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dc.contributor.authorBEREKET, ABDULLAH
dc.contributor.authorsAtay, Zeynep; Turan, Serap; Guran, Tulay; Furman, Andrzej; Bereket, Abdullah
dc.date.accessioned2022-03-12T18:06:06Z
dc.date.available2022-03-12T18:06:06Z
dc.date.issued2012
dc.description.abstractAim: To assess the prevalence of premature thelarche (PT) and pubarche in healthy 4- to 8-year-old girls and to investigate factors associated with early pubertal development. Method: Eight hundred and twenty girls were examined by two paediatric endocrinologists to determine Tanner staging. The effects of body mass index, gestational age, intrauterine growth status, age at the first tooth eruption, socio-economical status, maternal age of menarche and consumption of certain food items on early pubertal development were analysed through parametric and nonparametric tests. Results: The prevalence of PT and of premature pubarche was 8.9% and 4.3%, respectively. We found a strong association between the prevalence of PT and the body mass index standard deviation scores (BMI SDS). There were more girls with BMI SDS values above 1 in the PT group (56.1%) than among the remaining subjects (22.9%). Premature thelarche was not significantly associated with intrauterine growth, premature birth, socioeconomic status, age of first tooth eruption or maternal age of menarche. Similarly, the amount of milk, eggs, chicken or fish consumed was not associated with PT. None of the investigated factors were associated with premature pubarche. Conclusion: Occurrence of PT is strongly associated with BMI SDS. Studies investigating secular trends in pubertal development must consider a secular change in body mass index.
dc.identifier.doi10.1111/j.1651-2227.2011.02444.x
dc.identifier.eissn1651-2227
dc.identifier.issn0803-5253
dc.identifier.pubmed21854448
dc.identifier.urihttps://hdl.handle.net/11424/230838
dc.identifier.wosWOS:000298914000005
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofACTA PAEDIATRICA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdrenarche
dc.subjectBody mass index
dc.subjectPubarche
dc.subjectPuberty
dc.subjectThelarche
dc.subjectBODY-MASS INDEX
dc.subjectSEXUAL PRECOCITY
dc.subjectCHILDREN
dc.subjectAGE
dc.subjectPUBERTY
dc.subjectMENARCHE
dc.subjectEXPOSURE
dc.subjectTRENDS
dc.subjectONSET
dc.titleThe prevalence and risk factors of premature thelarche and pubarche in 4-to 8-year-old girls
dc.typearticle
dspace.entity.typePublication
local.avesis.idc7e81afc-5dc5-483b-8aff-b2a2f16ce08f
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPageE75
oaire.citation.issue2
oaire.citation.startPageE71
oaire.citation.titleACTA PAEDIATRICA
oaire.citation.volume101
relation.isAuthorOfPublication669e9474-4e39-453f-a4bc-4ede9cb5abac
relation.isAuthorOfPublication.latestForDiscovery669e9474-4e39-453f-a4bc-4ede9cb5abac

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