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In vitro antioxidant and cytotoxic activity of Muscari neglectum growing in Turkey

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dc.contributor.authorTAŞKIN, TURGUT
dc.contributor.authorsEroglu Ozkan, Esra; Demirci Kayiran, Serpil; Taskin, Turgut; Abudayyak, Mahmoud
dc.date.accessioned2022-03-14T09:03:27Z
dc.date.available2022-03-14T09:03:27Z
dc.date.issued2018-01-12
dc.description.abstractMuscari species have been used as antirheumatic, stomachic, diuretic, expectorant and anti verruca in folk medicine. The species have also been used as food for humans and animals in Turkey. In this study, the antioxidant and cytotoxic activities of different extracts obtained from Muscari neglectum were studied. The antioxidant capacities of the extracts were evaluated with DPPH free radical scavenging activity, metal chelating capacity and ABTS cation radical scavenging capacity assays. The cytotoxic potentials of the extracts were determined by MTT and LDH assays on HeLa-cells (human cancer cell line) and NRK-52E-cells (rat kidney cell line). The aqueous extracts from M. neglectum bulbs (IC50 : 2.83 +/- 0.54 mg/mL) and herba (IC 50 : 8.52 +/- 1.3 mg/mL) exhibited stronger DPPH free radical scavenging activity than other extracts, respectively. The ethanol extract from M. neglectum bulbs showed the highest ABTS (27.88 %) cation radical scavenging activity. According to the metal chelating activity test results, the aqueous extracts from M. neglectum herba and bulbs showed the strongest metal chelating activity (28.99% and 28.07%, respectively).
dc.identifier.doi10.12991/mpj.2018.43
dc.identifier.issn1309-0801
dc.identifier.urihttps://hdl.handle.net/11424/242279
dc.identifier.wosWOS:000432474800009
dc.language.isoeng
dc.publisherMARMARA UNIV, FAC PHARMACY
dc.relation.ispartofMARMARA PHARMACEUTICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMuscari neglectum
dc.subjectantioxidant activity
dc.subjectcytotoxic activity
dc.subjectTurkey
dc.subjectHYACINTHACEAE
dc.subjectASPARAGACEAE
dc.subjectPLANTS
dc.subjectASSAY
dc.titleIn vitro antioxidant and cytotoxic activity of Muscari neglectum growing in Turkey
dc.typearticle
dspace.entity.typePublication
local.avesis.ida5d3e16d-0df3-4a04-85da-642a8d8cfd82
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages6
oaire.citation.endPage79
oaire.citation.issue1
oaire.citation.startPage74
oaire.citation.titleMARMARA PHARMACEUTICAL JOURNAL
oaire.citation.volume22
relation.isAuthorOfPublication265414e9-485c-42b8-903a-c467f6b49b84
relation.isAuthorOfPublication.latestForDiscovery265414e9-485c-42b8-903a-c467f6b49b84

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