Publication:
The relationship between psychopathology and cognitive functions with cytokines in clinically stable patients with schizophrenia

Simple item page
dc.contributor.authorHAKLAR, GONCAGÜL
dc.contributor.authorsErgun, Serhat; Yanartas, Omer; Kandemir, Guler; Yaman, Ali; Yildiz, Mesut; Haklar, Goncagul; Sayar, Kemal
dc.date.accessioned2022-03-14T08:40:51Z
dc.date.available2022-03-14T08:40:51Z
dc.date.issued2018-01-02
dc.description.abstractOBJECTIVES: Inflammation and the cytokine hypotheses have been proposed for schizophrenia. Several proinflammatory and anti-inflammatory cytokines have been studied in drug-naive, first-episode, and/or chronic schizophrenia patients. However, there were limited data on clinical stable outpatients reflecting daily routine. The aim of this study was to compare the serum levels of cytokines, including transforming growth factor-beta (TGF-beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), between clinically stable patients with schizophrenia and healthy controls, as well as to examine the relationship between these inflammation parameters and clinical variables (positive and negative symptom severity and cognitive functions). METHODS: Thirty clinically stable outpatients with schizophrenia and 30 healthy controls with similar sex and age were included in this study. Serum IL-6, TGF-beta, and TNF-alpha levels were assessed by enzyme-linked immunosorbent assay (ELISA) and immunoenzyme microplate measurement, respectively. Illness severity was evaluated using the Positive and Negative Syndrome Scale (PANSS), and the cognitive functions of the participants were assessed using a broad neuropsychological test battery. RESULTS: The serum levels of IL-6 and TGF-beta were significantly higher in patients with schizophrenia compared to healthy controls (p = .048, p = .012). There was no significant difference between groups in terms of TNF-alpha levels (p = .726). Global impairment of cognitive functions was observed in the patient group compared to healthy controls, and PANSS scores and cognitive functions showed no correlation with cytokine levels (IL-6, TNF-alpha, and TGF-beta). CONCLUSIONS: The present study demonstrated an increased inflammatory response in clinically stable patients with schizophrenia compared to healthy controls. However, symptom severity and cognitive functions showed no correlation with cytokine levels. Further research studies are needed to clarify the effects of cytokine levels on schizophrenia symptomatology and etiopathogenesis.
dc.identifier.doi10.1080/24750573.2017.1380920
dc.identifier.eissn2475-0581
dc.identifier.issn2475-0573
dc.identifier.urihttps://hdl.handle.net/11424/242124
dc.identifier.wosWOS:000428201300011
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofPSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSchizophrenia
dc.subjectinflammation
dc.subjectcytokines
dc.subjectcognition
dc.subjectpsychopathology
dc.subject1ST EPISODE PSYCHOSIS
dc.subjectSYNDROME SCALE PANSS
dc.subjectC-REACTIVE PROTEIN
dc.subjectMEDICATION-NAIVE
dc.subjectSERUM-LEVELS
dc.subjectMETAANALYSIS
dc.subjectSYMPTOMS
dc.subjectINFLAMMATION
dc.subjectIMPAIRMENT
dc.subjectINDIVIDUALS
dc.titleThe relationship between psychopathology and cognitive functions with cytokines in clinically stable patients with schizophrenia
dc.typearticle
dspace.entity.typePublication
local.avesis.id00b06ed1-ffa6-4954-a1d7-d8f863c22899
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages7
local.journal.quartileQ4
oaire.citation.endPage72
oaire.citation.issue1
oaire.citation.startPage66
oaire.citation.titlePSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
oaire.citation.volume28
relation.isAuthorOfPublication27f9fd8a-7791-4b61-a4c5-518c52435a15
relation.isAuthorOfPublication.latestForDiscovery27f9fd8a-7791-4b61-a4c5-518c52435a15

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ergün et al. - 2018 - The relationship between psychopathology and cogni.pdf
Size:
1.07 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs