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Sequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control Study

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dc.contributor.authorBİLGİLİ, BELİZ
dc.contributor.authorsBilgin, Huseyin; Haliloglu, Murat; Yaman, Ali; Ay, Pinar; Bilgili, Beliz; Arslantas, Mustafa Kemal; Ozdemir, Filiz Ture; Haklar, Goncagul; Cinel, Ismail; Mulazimoglu, Lutfiye
dc.date.accessioned2022-03-14T09:04:56Z
dc.date.available2022-03-14T09:04:56Z
dc.date.issued2018
dc.description.abstractPurpose. The main purpose of this study was to investigate the dynamics of pentraxin 3 (PTX3) compared with procalcitonin (PCT) and C-reactive protein (CRP) in patients with suspicion of ventilator-associated pneumonia (VAP). Materials and Methods. We designed a nested case-control study. This study was performed in the Surgical Intensive Care Unit of a tertiary care academic university and teaching hospital. Ninety-one adults who were mechanically ventilated for >48 hours were enrolled in the study. VAP diagnosis was established among 28 patients following the 2005 ATS/IDSA guidelines. Results. The median PTX3 plasma level was 2.66 ng/mL in VAP adults compared to 0.25 ng/mL in non-VAP adults (p < 0.05). Procalcitonin and CRP levels did not significantly differ. Pentraxin 3, with a 2.56 ng/mL breakpoint, had 85% sensitivity, 86% specificity, 75% positive predictive value, and 92.9% negative predictive value for VAP diagnosis (AUC = 0.78). Conclusions. With the suspicion of VAP, a pentraxin 3 plasma breakpoint of 2.56 ng/mL could contribute to the decision of whether to start antibiotics.
dc.identifier.doi10.1155/2018/4074169
dc.identifier.eissn1918-1493
dc.identifier.issn1712-9532
dc.identifier.pubmed29861799
dc.identifier.urihttps://hdl.handle.net/11424/242429
dc.identifier.wosWOS:000433456900001
dc.language.isoeng
dc.publisherHINDAWI LTD
dc.relation.ispartofCANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectC-REACTIVE PROTEIN
dc.subjectATTRIBUTABLE MORTALITY
dc.subjectPROCALCITONIN
dc.subjectDIAGNOSIS
dc.subjectMARKER
dc.subjectPTX3
dc.titleSequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control Study
dc.typearticle
dspace.entity.typePublication
local.avesis.id8ac5624a-174f-4810-a7e5-9a511fe16e66
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber4074169
local.journal.numberofpages8
local.journal.quartileQ4
oaire.citation.titleCANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
oaire.citation.volume2018
relation.isAuthorOfPublicationc1a337e4-d6be-4d98-821d-1b76c3b3f287
relation.isAuthorOfPublication.latestForDiscoveryc1a337e4-d6be-4d98-821d-1b76c3b3f287

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